Effect of Emergency Percutaneous Coronary Intervention Combined with Sacubitril and Valsartan on the Cardiac Prognosis in Patients with Acute Myocardial Infarction

Figures & data

Table 1 General Characteristics of Patients in Two Groups

Variables	Treatment Group (n=39)	Control Group (n=39)	χ^2/t	P
Age (yr)	71.33 ± 10.52	68.00 ± 11.45	1.339	0.185
Gender (M/F)	28/11	31/8	0.626	0.429
Body mass index (kg/m^2)	22.12 ± 2.52	22.27 ± 2.31	0.274	0.785
Time from onset to admission (h)	6.15 ± 1.27	5.86 ± 1.25	1.029	0.307
Pre-existing diseases (n)		-
Hypertension	23	20	0.466	0.495
Diabetes	11	13	0.241	0.624

Table 2 Ventricular Remodeling of Patients in Two Groups Before and After Treatment

Group	n	LVESD (mm)		LVEDD (mm)		IVST (mm)
		Before	After	Before	After	Before	After
Treatment	39	43.84 ± 5.76	36.64 ± 5.08	55.84 ± 4.64	43.05 ± 5.08	9.77 ± 0.71	10.38 ± 0.85
Control	39	43.31 ± 4.36	42.04 ± 4.54	55.36 ± 6.55	47.34 ± 5.47	9.46 ± 0.79	10.03 ± 1.01
t		0.464	4.950	0.379	3.589	1.823	1.699
P		0.644	0.000	0.706	0.000	0.072	0.094

Table 3 Cardiac Function of Patients in Two Groups Before and After Treatment

Group	n	NT-proBNP (pg/mL)		LVEF (%)		6MWT (m)
		Before	After	Before	After	Before	After
Treatment	39	1569.20 ± 898.05	208.72 ± 90.69	47.89 ± 6.28	55.09 ± 3.43	300.91±60.02	597.42±62.44
Control	39	1375.19 ± 973.23	294.95 ± 93.21	48.59 ± 7.06	50.33 ± 3.97	300.97±60.23	455.52±62.22
t		0.916	4.136	0.463	5.666	0.004	10.053
P		0.363	0.000	0.645	0.000	0.996	0.000

Table 4 Serum Levels of HCY and CysC of Patients in Two Groups Before and After Treatment

Group	n	HCY (μmol/L)		CysC (mg/L)
		Before	After	Before	After
Treatment	39	18.78±4.23	9.13 ± 3.11	1.68±0.45	0.83 ± 0.16
Control	39	19.23 ± 4.55	13.97 ± 3.24	1.72±0.42	1.35 ± 0.19
t		0.452	6.730	0.358	13.074
P		0.652	0.000	0.721	0.000

Table 5 MACE in Two Groups After 3-Month Follow-Up

Group	n	Recurrent AMI	UA	malignant Arrhythmia	Repeat Revascularization	Rehospitalization Due to Heart Failure	Cardiac Death	Total
Treatment	39	0 (0)	1 (2.5)	0 (0)	0 (0)	1 (2.5)	0 (0)	2 (5)
Control	39	1 (2.5)	2 (5.1)	2 (5.1)	1 (2.5)	3 (7.9)	0 (0)	9 (23.1)
χ2		–	–	–	–	–	–	5.186
P		–	–	–	–	–	–	0.023