Pulmonary Function in Patients with Solitary Spinal Metastases: A Hospital-Based Cross-Sectional Study

Figures & data

Figure 1 Flowchart of patients’ selection. From January 2010 to December 2018, patients diagnosed with spinal metastases in six member institutions of Spine Metastatic Intergroup of China (SMIG) were reviewed (n=1706). 771 patients were meeting inclusion criteria, after excluded those no surgery performed or multiple vertebral patients (n=935). Of these, there were 736 patients having comprehensive medical records, particularly surgery and anesthetic records, as well as perioperative laboratory examinations removing those without medical record (n=35 cases). Excluded those patients with exclusion criteria (n=583), 153 patients were included in this study.

Table 1 Characteristics of Participants in This Study

Category	Men	Women	Total	P
Total	70(45.8)	83(54.2)	153
Age, means±SD	56.31±14.62	59.59±13.1	58.09±13.87
Age group, n (%)				0.390
< 50	16(22.9)	13(15.7)	29(19.0)
50 ~59	22(31.4)	21(25.3)	43(28.1)
60 ~69	20(28.6)	33(39.8)	53(34.6)
≥70	12(17.1)	16(19.3)	28(18.3)
Surgical site:				0.424
Cervical spine	6(8.6)	10(12)	16(10.5)
Thoracic	37(52.9)	39(47)	76(49.7)
Lumbar spine	26(37.1)	29(34.9)	55(35.9)
Sacral spine	1(1.4)	5(6)	6(3.9)
VC, means±SD (L)	2.86±0.89	2.18±0.59	2.49±0.81	<0.001
FEV1, means±SD (L)	2.35±0.84	1.84±0.52	2.07±0.73	<0.001
FVC, means±SD (L)	2.82±0.9	2.13±0.59	2.44±0.82	<0.001
FEV1/FVC, means±SD	82.69±11.13	86.39±7.27	84.7±9.39	0.015
MVV, means±SD (L)	117.92±14.26	93.89±10.91	104.89±17.34	<0.001
Preoperative laboratory indicators, means±SD:
Hemoglobin	142.59±19.63	125.61±13.13	133.38±18.44	<0.001
Lymphocyte percentage	25.22±9.7	28.57±11.43	27.04±10.77	0.055
Total albumin	39.46±5.13	39.67±4.25	39.58±4.66	0.785
Postoperative laboratory indicators, means±SD:
Hemoglobin	110.73±18.1	108.41±18.57	109.52±18.32	0.469
Lymphocyte percentage	11.09±6.54	11.96±6.73	11.54±6.63	0.450
Total albumin	29.54±5.42	30.33±5.64	29.94±5.52	0.417

Abbreviations: VC, Vital capacity; FEV1, Forced Expiratory Volume in the first second; FVC, Forced vital capacity; MVV, Maximal voluntary ventilation.

Table 2 Analysis of Characteristics of Metastatic Tumors in Different Sites

Category	Cervical Spine	Thoracic	Lumbar Spine	Sacral Spine	P
Age group, n (%)					0.512
< 50	3(18.8)	11(14.5)	13(23.6)	2(33.3)
50 ~59	6(37.5)	18(23.7)	18(32.7)	1(16.7)
60 ~69	4(25.0)	33(43.4)	15(27.3)	1(16.7)
≥70	3(18.8)	14(18.4)	9(16.4)	2(33.3)
VC	2.59±1.07	2.37±0.76	2.65±0.76	2.26±0.45	0.223
FEV1	2.19±0.98	1.95±0.68	2.22±0.68	1.96±0.45	0.172
FVC	2.53±1.09	2.33±0.76	2.6±0.76	2.23±0.49	0.244
FEV1/FVC	85.51±8.69	83.7±9.77	85.52±9.77	87.62±5.34	0.579
MVV	102.39±16.48	105.08±15.36	106.46±15.36	94.55±13.07	0.406
Preoperative laboratory indicators:
Hemoglobin	137±20.24	132.09±18.79	135.09±18.79	124.33±19.26	0.410
Lymphocyte percentage	28.61±7.39	26.18±11.35	27.7±11.35	27.65±13.42	0.792
Total albumin	41.31±3.29	38.82±5.18	40.13±5.18	39.32±2.93	0.173
Postoperative laboratory indicators:
Hemoglobin	121.31±17.85	107.49±18.95	109.89±18.95	104.17±24.32	0.078
Lymphocyte percentage	11.11±4.93	10.94±5.86	12.84±5.86	9.35±7.66	0.386
Total albumin	32.95±4.32	29.28±5	29.69±5	32.25±10.83	0.115

Abbreviations: VC, Vital capacity; FEV1, Forced Expiratory Volume in the first second; FVC, Forced vital capacity; MVV, Maximal voluntary ventilation.

Table 3 Relationship Between BMI and Respiratory Function in Patients with Spinal Metastases

Category	VC		FEV1		FVC		FEV1/FVC		MVV
	Mean±SD	P	Mean±SD	P	Mean±SD	P	Mean±SD	P	Mean±SD	P
Total
BMI group:		0.028		0.026		0.026		0.284		0.623
Low body weight group	1.66±0.62		1.27±0.70		1.59±0.67		78.41±21.36		104.31±28.59
Normal weight group	2.38±0.79		2.01±0.66		2.35±0.79		86.06±9.48		103.09±17.01
Overweight group	2.65±0.78		2.20±0.71		2.60±0.79		84.44±7.78		106.83±17.11
Obesity group	2.42±0.90		1.98±0.84		2.35±0.92		83.44±10.35		102.87±16.58
Man		0.304		0.341		0.321		0.621		0.863
BMI group:
Low body weight group	2.03±0.47		1.62±0.71		2.02±0.44		77.54±23.74		120.96±23.35
Normal weight group	2.77±0.82		2.3±0.72		2.74±0.83		84.25±10.49		117.83±13.25
Overweight group	3±0.96		2.49±0.9		2.97±0.96		82.9±10.65		118.7±14.81
Obesity group	2.87±0.83		2.25±0.88		2.77±0.9		79.77±10.72		114.64±13.89
Woman		0.005		0.005		0.003		0.429		0.029
BMI group:
Low body weight group	1.1±0.25		0.74±0.21		0.94±0.04		79.72±26.31		79.32±9.84
Normal weight group	2.09±0.62		1.79±0.53		2.05±0.61		87.46±8.52		91.68±8.80
Overweight group	2.35±0.42		1.97±0.38		2.30±0.43		85.71±3.88		97.04±11.95
Obesity group	1.97±0.76		1.71±0.74		1.93±0.77		87.12±9.01		91.11±8.96

Abbreviations: VC, Vital capacity; FEV1, Forced Expiratory Volume in the first second; FVC, Forced vital capacity; MVV, Maximal voluntary ventilation.