Association Between Serum Irisin Levels and ST-Segment Elevation Myocardial Infarction

Figures & data

Table 1 Baseline Demographics, Characteristics, and Comorbidities of the Subjects

	Control (n = 46)	STEMI (n = 44)	P value
Age (years; mean ± SD (range))	55 ± 10 (22–82)	59 ± 12 (32–88)	0.151^t
Gender (male; n (%))	30 (65)	32 (72)	0.499^#
Body weight (kg; mean ± SD)	76.1 ± 16.9	75.1 ± 13.7	0.818^m
Systemic HT (n (%))	26 (59.1)	22 (47.8)	0.300^#
DM, n, (%)	8 (17.4)	17 (38.6)	0.034^#
Current smoker (n (%))	30 (65.2)	27 (61.4)	0.827^#
Systolic BP (mmHg; mean ± SD)	130 ± 20	120 ± 32	0.103^m
Angina pectoris (1 hour; n (%))	13 (28.2)	22 (50)	0.034^#
Prior PCI (n (%))	–	39 (88.6)
Prior coronary artery bypass graft (n (%))	–	–
Prior thrombectomy (n (%))	–	5 (11.3)
ECG findings
HR (mm/seconds; mean ± SD)	72.8 ± 16.2	63.9 ± 18.7	0.020^m
ST-elevation (mV)	-	0.3 ± 0.11	<0.001^m
QTc interval (msec; mean ± SD)	306.5 ± 9.2	360.3 ± 9.1	<0.001^t
Infarct-related artery (n (%))
LAD	-	22 (50)
CX	-	1 (2.2)
RCA	-	17 (38.6)
CX and RCA	-	4 (9.1)
Biochemical analysis at admission (mean ± SD)
Urea (mg/dL)	39 ± 16.1	50.3 ±19.8	0.004^m
Creatinine (mg/dL)	0.93 ± 0.82	1.0 ± 0.8	0.198^m
Total cholesterol (mg/dL)	186 ± 46	201.1 ± 52.9	0.154^t
TG (mg/dL)	166.1 ± 100.3	100.7 ± 32.7	<0.001^m
LDL (mg/dL)	181.3 ± 50.5	157.6 ± 44.9	0.021^t
HDL (mg/dL)	44.3 ± 11.9	43.6 ± 10.3	0.824^m
Fasting glucose (mg/dL)	107± 37.1	144 ± 48.8	<0.001^m
Peak cTi (ng/L)	4.9 ± 1.6	4132.1 ± 1080.9	<0.001^m
Irisin	12.5 ± 8.9	4.95 ± 2	<0.001^m

Notes: “-”Denotes no value/number. ^tt-test, ^#Chi-square test, ^mMann–Whitney U-test.

Abbreviations: BP, blood pressure; CX, circumflex artery; cTi, cardiac troponin-I; DM, diabetes mellitus; HDL, high-density lipoprotein; HR, heart rate; HT, hypertension; LAD, left anterior descending artery; LDL, low-density lipoprotein; PCI, percutaneous coronary intervention; RCA, right coronary artery; TG, triglyceride.

Table 2 Correlations Between Serum Irisin, cTi Levels and QTc Interval

	Serum Irisin
Parameters	Spearman’s r	p value
cTi (ng/mL)	−0.595	<0.001
QTc interval (msec)	−0.250	<0.05

Note: p values lower than 0.05 were considered significant.

Abbreviation: cTi, cardiac troponin-I.

Figure 1 Serum irisin levels in control subjects and AMI patients (****p<0.0001^m).

Table 3 Diagnostic Values of Irisin and Other Variables in All Groups

Variables	Cut-Off	AUC	Sensitivity	Specificity	p
Peak cTi	> 16.5	0.98	93%	98%	<0.001
Irisin	< 6.71	0.93	93%	78%	<0.001
QTc interval	> 16.5	0.71	61%	76%	<0.001

Abbreviations: cTi, cardiac troponin I; AUC, area under the curve.

Figure 2 ROC analysis of irisin, peak cTi and QTc interval for STEMI variables and control groups.

Table 4 Regression Analysis of Variables for STEMI

	Univariate			Multivariate
	Odds Ratio	95% C.I.for EXP(B)	p	Odds Ratio	95% C.I.for EXP(B)	p
		Lower–Upper			Lower–Upper
Peak cTi	0.283	0.627–0.905	0.002	0.290	0.525–1.066	0.108
Irisin	1.047	1.756–4.619	0.000	1.472	0.304–62.423	0.278
Urea	0.037	0.940–0.990	0.008	0.096	0.806–1.503	0.548
LDL	0.011	1.001–1.020	0.011	0.015	0.952–1.083	0.639
TG	0.022	1.010–1.035	0.001	0.048	0.98–1.124	0.170