Could the Systemic Immune Inflammation Index Predict Diagnosis, Recovery Time, Hypothyroidism, and Recurrence Rates in Subacute Thyroiditis?

Figures & data

Table 1 The Distribution of Gender and the Means and Standard Deviations of the Participants’Age

	SAT Group (n = 69)	Control Group (n = 59)	Total (n = 128)	p-value
Age, mean (SD)	42.4 (8.9)	41.4 (9.05)	41.9 (8.9)	0.738^a
Sex, frequency (%)				0.840^b
Female	52 (75.4)	43 (72.9)	95 (74.2)
Male	17 (24.6)	16 (27.1)	33 (25.8)

Notes: Categorical data were demonstrated as numbers and percentages (%), ^a: Two sample t-test, ^b: Chi-squared test.

Abbreviation: SAT, subacute thyroiditis.

Table 2 The Medians, Minimum, and Maximum Ranges of Parameters of the SAT Patients at the Time of Diagnosis and Healthy Controls

Parameters	SAT Group (n = 69)	Control Group (n = 59)	P-value
SII	1172 (475–2558)	344 (177–655)	0.000^a
Neu (10^3/mm^3)	5.84 (3.6–12.3)	3.54 (1.8–5.5)	0.000^a
Lym (10^3/mm^3)	1.98 (1.1–3.6)	2.57 (1.4–3.7)	0.000^a
Mono (10^3/mm^3)	0.73 (0.4–1.5)	0.49 (0.1–0.8)	0.000^a
PLT (10^9/L)	370 (196–645)	252 (158–348)	0.000^a
ESR (mm/h)	49 (19–112)	6 (1–33)	0.000^a
CRP (mg/L)	57 (20–248)	1.63 (0–14)	0.000^a
SLR	23 (0–72)	2 (0–13)	0.000^a
CLR	26 (5–174)	1.79 (1.1–3.4)	0.000^a
NLR	2.91 (1.3–5.9)	1.37 (0.7–2.3)	0.000^a
LMR	2.78 (1.5–6.1)	5 (2–12)	0.000^a
PLR	185 (98–353)	98 (49–219)	0.000^a
Recovery time (days)	35 (15–80)	-	-

Notes: Statistically significant, ^ap < 0.05, Mann–Whitney U-test, variables were presented as medians (minimum–maximum).

Abbreviations: SAT, subacute thyroiditis; SII, Systemic Immune Inflammation Index; Neu, neutrophil; Lym, lymphocyte; Mono, monocyte; PLT, platelet; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; SLR, sedimentation-to-lymphocyte ratio; CLR, CRP-to-lymphocyte ratio; NLR, neutrophil-to-lymphocyte ratio; LMR, lymphocyte-to-monocyte ratio; PLR, platelet-to- lymphocyte ratio.

Table 3 Recovery Time Correlations with Other Inflammatory Markers in Patients with Subacute Thyroiditis Using Spearman Correlation Analysis

Recovery time	r	p-value
SII	0.476	0.000^a
PLR	0.262	0.030^a
LMR	−0.216	0.074
NLR	0.209	0.085
ESR	0.163	0.181
CRP	0.122	0.318
SLR	0.168	0.168
CLR	0.192	0.941

Note: ^ap < 0.05, Spearman correlation analysis.

Abbreviations: r, Spearman correlation coefficient; NLR, neutrophil–-to-ratio; LMR, lymphocyte-to-monocyte ratio; PLR, platelet-to-lymphocyte ratio; SII, Systemic Immune Inflammation Index; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; SLR, sedimentation-to-lymphocyte ratio; CLR, CRP-to-lymphocyte ratio.

Table 4 Correlation Analyses Between Systemic Immune Inflammation Index and Recovery Time in Terms of Medical Treatment in Patient Group

	SII	P value
	r
Recovery time
NSAID (n = 31)	0.323	0.076
MPS (n = 38)	0.495	0.002^a
Total (n = 69)	0.476	0.000^a

Note: ^ap < 0.05, Spearman correlation analysis.

Abbreviations: SII, Systemic Immune Inflammation Index; NSAID, non-steroidal anti-inflammatory drugs; MPS, methylprednisolone.

Table 5 Comparisons of Some Parameters According to the Type of SAT Treatment

	NSAID (n = 31)	MPS (n = 38)	P value
SII	898 (475–2044)	1287 (595–2558)	0.007^a
ESR (mm/h)	40 (19–98)	53 (26–112)	0.007^a
Recurrence (n)	0	8	0.007^a
Recovery time (day)	30 (15–65)	37 (20–80)	0.023^a

Notes: ^ap < 0.05; Mann–Whitney U-test, variables were presented as medians (minimum–maximum).

Abbreviations: SII, Systemic Immune Inflammation Index; ESR, erythrocyte sedimentation rate; NSAID, non-steroidal anti-inflammatory drugs; MPS, methylprednisolone.

Table 6 Comparisons of Laboratory Test Results and Recovery Time of the Patients with and Without Recurrence

	Recurrence (+) (n = 8)	(-) (n = 61)	p value
TSH (mIU/L)	0.13 (0.008–1.110)	0.008 (0.000–0.49)	0.046^a
ESR (mm/h)	68 (33–112)	48 (19–108)	0.035^a
Recovery time (day)	55 (33–80)	30 (17–70)	0.000^a
SII	1376 (475–2490)	1178 (495–2558)	0.261

Notes: ^ap < 0.05; Mann–Whitney U-test. Non-normally distributed variables were presented as medians (minimum–maximum).

Abbreviations: SII, Systemic Immune Inflammation Index; ESR, erythrocyte sedimentation rate; TSH, thyroid stimulating hormone.