Figures & data
Figure 1 Immunological checkpoints and combination therapies of CRC. The mismatch repair (MMR)/microsatellite instability (MSI) system is the most important indicator for CRC classification. ICIs have a significant effect in patients with dMMR/MSI-H who can benefit from them.The pMMR/MSS population has no obvious benefits due to its inherent immunosuppressive characteristics, low tumor lymphocyte infiltration level, and low tumor mutation burden (TMB). The combination of ICIs and other treatment schemes for pMMR/MSS CRC patients may achieve a certain effect due to the change in tumor microenvironment (By Figdraw).
