ALDH2 rs671 Polymorphism Likely a Risk Factor for Hemorrhagic Stroke: A Hospital-Based Study

Figures & data

Table 1 Comparison of Clinical Characteristics Between Patients with Hemorrhagic Stroke and Controls

Clinical Characteristics	Total (n=844)	Controls (n=515)	Hemorrhagic Stroke (n=329)	P values
Age (years)
<60, n(%)	318(37.7%)	206(40.0%)	112(34.0%)	0.181
60–70, n(%)	241(28.6%)	138(26.8%)	103(31.3%)
>70, n(%)	285(33.8%)	171(33.2%)	114(34.7%)
Mean age	63.17±14.64	62.15±15.85	64.76±12.38	0.011
Gender
Male, n(%)	576(68.2%)	362(70.3%)	214(65.0%)	0.112
Female, n(%)	268(31.8%)	153(29.7%)	115(35.0%)
History of smoking, n(%)	211(25.0%)	169(32.8%)	42(12.8%)	<0.001
History of alcohol consumption, n(%)	99(11.7%)	87(16.9%)	12(3.6%)	<0.001
Hypertension, n(%)	396(46.9%)	127(24.7%)	269(81.8%)	<0.001
Diabetes, n(%)	148(17.5%)	80(15.5%)	68(20.7%)	0.055
TG, mmol/L	1.49±1.99	1.52±2.34	1.45±1.26	0.599
TC, mmol/L	4.38±1.51	4.21±1.58	4.64±1.36	<0.001
HDL-C, mmol/L	1.23±0.46	1.18±0.47	1.30±0.45	<0.001
LDL-C, mmol/L	2.37±0.95	2.24±0.94	2.57±0.92	<0.001
Apo-A1, g/L	1.00±0.35	0.94±0.33	1.10±0.35	<0.001
Apo-B, g/L	0.75±0.28	0.72±0.26	0.81±0.29	<0.001

Table 2 The Prevalence of ALDH2 rs671 Variants in Cases and Controls

	Total (n, %)	Controls (n, %)	Hemorrhagic Stroke (n, %)	P value
Genotypes
G/G	519(61.5%)	335(65.0%)	184(55.9%)	0.021
G/A	281(33.3%)	158(30.7%)	123(37.4%)
A/A	44(5.2%)	22(4.3%)	22(6.7%)
G/G + G/A	800(94.8%)	493(95.7%)	307(93.3%)
G/A + A/A	325(38.5%)	180(35.0%)	145(44.1%)
Alleles
G	1319(78.1%)	828(80.4%)	491(74.6%)	0.005
A	369(21.9%)	202(19.6%)	167(25.4%)
HWE (χ^2, P)	χ^2=0.546, P=0.460	χ^2=0.375, P=0.540	χ^2=0.055, P=0.814

Abbreviation: HWE, Hardy-Weinberg equilibrium.

Table 3 Clinical Characteristics of Patients with Hemorrhagic Stroke Stratified by ALDH2 rs671 Variants

Clinical Characteristics	G/G (n=184)	G/A (n=123)	A/A (n=22)	P values	G Allele (G/G + G/A) (n=307)	A Allele (G/A + A/A) (n=145)	P values
Age (years)
<60, n(%)	70(38.0%)	34(27.6%)	8(36.4%)	0.069	104(33.9%)	42(29.0%)	0.270
60–70, n(%)	60(32.6%)	40(32.5%)	3(13.6%)		100(32.6%)	43(29.7%)
>70, n(%)	54(29.3%)	49(39.8%)	11(50.0%)		103(33.6%)	60(41.4%)
Mean age	63.20±12.02	66.46±12.21	68.32±14.67	0.029	64.51±12.18	66.74±12.57	0.072
Gender
Male, n(%)	119(64.7%)	85(69.1%)	10(45.5%)	0.107	204(66.4%)	95(65.5%)	0.915
Female, n(%)	65(35.3%)	38(30.9%)	12(54.5%)		103(33.6%)	50(34.5%)
History of smoking, n(%)	24(13.0%)	16(13.0%)	2(9.1%)	1.000	40(13.0%)	18(12.4%)	0.882
History of alcohol consumption, n(%)	9(4.9%)	3(2.4%)	0(0)	0.485	12(3.9%)	3(2.1%)	0.406
Hypertension, n(%)	154(83.7%)	99(80.5%)	16(72.7%)	0.353	253(82.4%)	115(79.3%)	0.439
Diabetes, n(%)	35(19.0%)	28(22.8%)	5(22.7%)	0.692	63(20.5%)	33(22.8%)	0.623
TG, mmol/L	1.49±1.41	1.45±1.10	1.04±0.38	0.280	1.48±1.29	1.39±1.03	0.478
TC, mmol/L	4.67±1.41	4.61±1.35	4.57±1.02	0.904	4.64±1.38	4.60±1.30	0.760
HDL-C, mmol/L	1.34±0.52	1.25±0.35	1.29±0.35	0.293	1.30±0.46	1.26±0.35	0.306
LDL-C, mmol/L	2.57±0.93	2.58±0.95	2.57±0.83	0.996	2.57±0.93	2.58±0.93	0.963
Apo-A1, g/L	1.11±0.37	1.09±0.31	1.09±0.35	0.865	1.10±0.35	1.09±0.31	0.713
Apo-B, g/L	0.82±0.29	0.81±0.31	0.78±0.21	0.831	0.81±0.30	0.80±0.29	0.737

Table 4 Logistic Regression Analysis of Risk Factors Associated with Hemorrhagic Stroke

Variables	Genotypes	Unadjusted Values		Adjusted Values
		OR (95% CI)	P value	Adjusted OR (95% CI)	P value
Age (≤65/>65)		0.923(0.700–1.219)	0.574	1.412(0.991–2.012)	0.056
Gender (Male/Female)		0.787(0.586–1.056)	0.111	1.711(1.154–2.538)	0.008
History of smoking (Yes/No)		0.300(0.206–0.435)	<0.001	0.340(0.203–0.569)	<0.001
History of alcohol consumption (Yes/No)		0.186(0.100–0.346)	<0.001	0.521(0.238–1.140)	0.103
Hypertension (Yes/No)		13.697(9.709–19.324)	<0.001	16.095(10.958–23.641)	<0.001
Diabetes (Yes/No)		1.417(0.990–2.026)	0.056	0.901(0.579–1.403)	0.645
ALDH2 rs671 polymorphism
	G/G	1.000(reference)
	G/A	1.417(1.054–1.906)	0.021	1.679(1.151–2.450)	0.007
	A/A	1.821(0.982–3.377)	0.057	2.516(1.132–5.591)	0.024

Abbreviations: OR, odds ratio; CI, confidence interval.

Data Sharing Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.