Clinical Value of Combined Multi-Indicator Tests in Diagnosis of Benign Ovarian

Figures & data

Table 1 Basic Information of the Study Population

Variables	Patients (n=150)	Control (n=104)	t/Z	P
Age (years)	31.72±7.51	31.29±6.79	0.738	0.461
LH (mIU/mL)	5.19 (3.11, 8.07)	4.39 (3.06, 5.91)	1.595	0.111
FSH (mIU/mL)	4.83 (3.32, 6.12)	5.09 (4.12, 6.20)	1.271	0.204
T (nmol/L)	1.07±0.34	1.02±0.32	1.000	0.318
E2 (pmol/L)	291.12 (140.93, 472.80)	172.57 (108.67, 340.61)	3.581	<0.001
AMH (ng/mL)	2.68 (1.33, 4.59)	2.65 (1.22, 4.43)	0.460	0.646
AFP (ng/mL)	1.90 (1.30, 3.00)	2.50 (1.70, 3.40)	3.227	0.001
CEA (ng/mL)	1.20 (0.80, 1.75)	1.20 (0.90, 1.80)	1.233	0.218
CA125 (U/mL)	21.40 (13.95, 53.70)	12.00 (8.50, 18.20)	7.100	<0.001
CA199 (U/mL)	14.10 (6.65, 27.70)	7.70 (3.50, 15.00)	4.618	<0.001

Table 2 Multi-Factor Logistic Regression Analysis of Patients with Benign Ovarian Tumors

Indicators	B-value	B-value Standard Error	Wald	OR (95% CI)	P
E2	0.001	0.001	7.214	1.001 (1.000, 1.003)	0.007
AFP	−0.071	0.052	1.823	0.932 (0.841, 1.032)	0.177
CA125	0.083	0.018	20.113	1.086 (1.048, 1.126)	<0.001
CA199	0.045	0.015	9.316	1.046 (1.016, 1.077)	0.002

Table 3 One-Way Logistic Regression Analysis versus Multivariate Logistic Regression Analysis in Patients with Benign Ovarian Tumors

Indicators	One-Way Logistic Regression			Multi-Factor Logistic Regression
	OR	OR95%Cl	P	OR	OR95%Cl	P
E2	1.001	1.000–1.002	0.014	1.001	1.000–1.002	0.019
CA125	1.086	1.050–1.123	<0.001	1.085	1.047–1.125	<0.001
CA199	1.059	1.032–1.087	<0.001	1.047	1.017–1.078	0.002

Table 4 Correlation Analysis Between AMH and Various Indicators

	Age	LH	FSH	T	E2	AFP	CEA	CA125	CA199
ρ (rho)	−0.459	0.103	−0.079	0.255	−0.280	−0.052	−0.009	0.063	0.107
P	<0.001	0.107	0.216	<0.001	<0.001	0.414	0.883	0.322	0.094

Table 5 The Value of Each Single Index in the Diagnosis and Prediction of Benign Ovarian Tumors

Indicators	AUC	P	95% CI	Cut-Off Threshold	Sensitivity (%)	Specificity (%)
E2	0.632	<0.001	0.562–0.702	290.74	50.0	75.0
CA125	0.762	<0.001	0.705–0.819	18.70	56.7	83.7
CA199	0.671	<0.001	0.605–0.737	17.40	43.6	84.5

Table 6 The Predictive Value of Combination Diagnosis in Benign Ovarian Tumors

Indicators	AUC	P	95% CI	Logistic Y	Sensitivity (%)	Specificity (%)
E2+CA125	0.777	<0.001	0.721–0.833	0.128	66.7	76.9
E2+CA199	0.717	<0.001	0.653–0.780	−0.168	82.6	51.5
CA125+CA199	0.783	<0.001	0.728–0.838	0.423	61.1	86.4
E2+CA125+CA199	0.805	<0.001	0.753–0.858	−0.022	77.2	70.9

Figure 1 ROC curves for the E2, CA125, and CA199 indicators for the diagnosis of benign ovarian tumors.