Establishment and Validation of the Risk Nomogram of Poor Prognosis in Patients with Severe Pulmonary Infection Complicated with Respiratory Failure

Figures & data

Figure 1 The general data selection process.

Table 1 Univariate Analysis on Prognosis of Patients [Cases (%), ()]

Groups	Good Prognosis Group (n=118)	Poor Prognosis Group (n=100)	χ^2/t	P
Age (year)	63.78±5.35	68.91±6.24	6.536	<0.001
Gender (%)			0.396	0.529
Female	40 (33.90)	38 (38.00)
Male	78 (66.10)	62 (62.00)
BMI (kg/m^2)	22.73±2.74	23.06±2.75	0.885	0.377
Causes of pneumonia			2.453	0.117
Bacterial	50 (42.37)	53 (53.00)
Viral	68 (57.63)	47 (47.00)
Type of pneumonia			2.813	0.094
Hospital-acquired	55 (46.61)	58 (58.00)
Community-acquired	63 (53.39)	42 (42.00)
Respiratory failure type (%)			1.674	0.196
Type I	67 (56.78)	48 (48.00)
Type II	51 (43.22)	52 (52.00)
Hypertension history (%)			1.857	0.173
Yes	39 (33.05)	42 (42.00)
No	79 (66.95)	58 (58.00)
Diabetes history (%)			2.407	0.121
Yes	31 (26.27)	36 (36.00)
No	87 (73.73)	64 (64.00)
Smoking history (%)			3.210	0.073
Yes	38 (32.20)	44 (44.00)
No	80 (67.80)	56 (56.00)
History of mechanical ventilation (%)			7.535	0.006
Yes	43 (36.44)	55 (55.00)
No	75 (63.56)	45 (45.00)
Number of combined basic diseases (number)			11.464	0.001
<5	112 (94.92)	80 (80.00)
≥5	6 (5.08)	20 (20.00)
APACHE II score (score)			14.420	<0.001
≤20	82 (69.49)	44 (44.00)
>20	36 (30.51)	56 (56.00)
MODS score (score)			13.727	<0.001
≤10	71 (60.17)	35 (35.00)
>10	47 (39.83)	65 (65.00)
PSI score (score)			17.219	<0.001
≤90	66 (55.93)	28 (28.00)
>90	52 (44.07)	72 (72.00)
Multi-drug resistant bacterial infection (%)			11.030	0.001
Yes	30 (25.42)	47 (47.00)
No	88 (74.58)	53 (53.00)
Oxygenation index (mmHg)	137.26±29.53	123.20±21.64	3.947	<0.001
PLT (×10^9/L)	108.90±20.27	107.84±22.35	0.367	0.714
WBC (×10^9/L)	13.68±2.25	14.14±2.07	1.560	0.120
Alb (g/L)	32.74±6.83	27.74±6.25	5.599	<0.001
NLR	3.27±0.50	3.36±0.76	1.047	0.296
AST (U/L)	32.09±2.08	32.16±1.19	0.298	0.766
ALT (U/L)	22.70±4.24	23.19±6.46	0.671	0.503

Table 2 The Assignment of Variables

Variables		The Assignment
X1	Age	0=<65 years old, 1=≥65 years old
X2	History of mechanical ventilation	0=no, 1=yes
X3	Number of combined basic diseases	0=<5, 1=≥5
X4	APACHE II score	0=≤20, 1≤20
X5	MODS score	0=≤10, 1≤10
X6	PSI score	0=≤90, 1≤90
X7	Multi-drug resistant bacterial infection	0=no, 1=yes
X8	Oxygenation index	0≤130mmHg, 1=≤130mmHg
X9	Alb	0≤30 g/L, 1=≤30g/L
Y	Prognosis	0=good, 1=poor

Table 3 Multivariate Logistic Regression Analysis of Prognostic Factors of Severe Pulmonary Infection Complicated with Respiratory Failure

Indicators	B value	SE value	Wald value	P value	OR value	95% CI
						Lower Limit	Upper Limit
X1	0.420	0.526	1.521	0.364	1.807	1.614	2.483
X2	0.210	0.382	1.292	0.528	1.241	0.558	2.360
X3	1.241	0.412	4.796	0.034	3.091	1.233	7.838
X4	1.179	0.471	6.408	0.009	3.307	1.563	7.234
X5	0.925	0.386	5.460	0.017	2.505	1.169	5.878
X6	1.185	0.403	8.258	<0.001	3.142	1.697	6.296
X7	0.948	0.325	8.209	<0.001	2.513	1.322	5.183
X8	−0.648	0.521	2.382	0.103	0.702	0.064	0.880
X9	−1.084	0.408	4.597	0.037	0.370	0.265	0.952

Figure 2 Construction of risk prediction model.

Figure 3 Calibration curve for external validation of nomograph model.

Figure 4 ROC curve for the validation of predictive value of risk prediction model.