The Effects of Prophylactic Intravenous Lignocaine vs Vecuronium on Succinylcholine-Induced Fasciculation and Postoperative Myalgia in Patients Undergoing Elective Surgery at Debre Markos Comprehensive Specialized Hospital, Ethiopia, 2022: Prospective Cohort Study

Figures & data

Table 1 Grade of Succinylcholine-Induced Fasciculation and Postoperative Myalgia in Patients Undergoing Elective Surgery

Grading of	Fasciculation	Postoperative Myalgia
0 = Absent	No fasciculation	Absence of pain other than surgical pain
1 = Mild	Fasciculation of eyes, face, neck, or fingers only	Muscle stiffness or pains, on deep breathing
2 = Moderate	Fasciculation involving limbs and/or trunk	Muscle pains spontaneously complained by the patient
3 = severe	Movement of limbs and/or trunk requiring forceful retention	Severe incapacitating, generalized muscle pain

Table 2 Demographics and Study Variables of the Respondents

Socio-Demographics	Lidocaine Group (n = 55)	Vecuronium Group (n = 55)	P-value
Age, years, mean ±SD	27.3 ± 13.5	29.5 ±10.3	0.43
Male/female ratio	26:29	30:25	0.13
ASA I:ASA II ratio	35:20	31:24	0.07
BMI (kg/m2)	20.93±2.9	21.8±3.2	0.20
Duration of surgery (hr.)	1.83± 0.30	1.90±0.25	0.09
Tramadol in 48hr postoperatively (mean ±SD)	165±57(72–205)	180±78(97–250)	0.06
Diclofenac in 48hr postoperatively (mean ±SD)	100±37(52–115)	120±48(67–156)	0.08
Pethidine in 48hr postoperatively (mean ±SD)	50±35(43–130)	80±55(60–140)	0.30
Morphine in 48hr postoperatively (mean ±SD)	30±15(23–60)	67±35(56–113)	0.34

Note: (mean ±SD) = in range.

Abbreviations: ASA, American Society of Anesthesiologists; BMI, body mass index; hr, hour; SD, standard deviation.

Figure 1 Distribution of the respondents in the two groups for various surgical procedures, 2022 (n = 110).

Table 3 Comparison of Incidence and Severity of Succinylcholine-Induced Fasciculation During Induction Among Elective Surgical Patients (n = 110)

Fasciculation		Vecuronium Group (n = 55)	Lidocaine Group (n=55)	P value
Grading	Nil	47(85.4%)	44(80%)	0.007
	Mild	8(14.6%)	8(14.5%)
	Moderate	0	3(5.5%)

Table 4 Comparison of Postoperative Succinylcholine-Induced Myalgia Between the Two Groups in Incidence and Severity Among Elective Surgical Patients Under General Anesthesia Within 48hrs (n = 110)

Groups	Myalgia	1 Hours	P-value	24 Hours	P-value	48 Hours	P-value
Vecuronium	Nil	42(763%)	0.04	38(69.1%)	<0.001	46(83.6%)	0.012
	Mild	9(16.3%)		12(21.8%)		6(10.9%)
	Moderate	4(7.4%)		5(9.1%)		3(5.5%)
Lidocaine	Nil	49(89.1%)	0.31	35(63.7%)	<0.001	50(90.9%)	0.08
	Mild	6(10.9%)		13(23.6%)		5(9.1%)
	Moderate	0%		7(12.7%)		0%