Clinical Significance of MMP7 Levels in Colorectal Cancer Patients Receiving FOLFOX4 Chemotherapy Treatment

Figures & data

Table 1 Demographic Data of CRC Patients and Healthy Controls

Item	CRC Patients	Volunteer	p
Number	216	216
Age			0.352
>60	99	95
≤60	117	121
Gender			0.245
Male	110	103
Female	106	113
Hyperlipidemia patients	15	13	0.938
Alcohol user	11	9	0.865
Hypertension patients	9	10	0.915
CHD patients	8	9	0.284
Diabetic	5	6	0.459

Abbreviations: CRC, colorectal cancer; CHD, coronary heart disease.

Table 2 Relationship Between Clinical Features and MMP7 Expression

Factors	Serum MMP7				p
	Low Expression (108)		High Expression (108)
	Number	%	Number	%
Age					0.645
>60	55	50.9	54	50
≤60	53	49.1	54	50
Gender					0.594
Male	51	47.2	59	54.6
Female	57	52.8	49	45.4
Histological grade					0.012
Well	76	70.4	25	23.1
Moderately, poorly	32	29.6	83	76.9
Tumor size					0.009
<20 mm (small)	74	68.5	21	19.4
>21 mm (large)	34	31.5	87	80.6
TNM stages					0.027
I+II	81	75	34	31.5
III+IV	27	25	74	68.5
Depth of tumor invasion					0.019
m^a, sm, mp, ss	69	63.9	36	33.3
se, si	39	36.1	72	66.7
Lymph node metastasis					0.357
Absent	60	55.6	53	49.1
Present	48	44.4	55	50.9
Lymphatic invasion					0.254
Absent	57	52.8	44	40.7
Present	51	47.2	64	59.3
Venous invasion					0.219
Absent	72	66.7	71	65.7
Present	36	33.3	37	34.3
Liver metastasis					0.309
Absent	81	75	73	67.6
Present	27	25	35	32.4
Peritoneal dissemination					0.346
Absent	92	85.2	97	89.8
Present	16	14.8	11	10.2

Notes: ^aTumor invasion of mucosa (m), submucosa (sm), muscularis propria (mp), subserosa (ss), penetration of serosa (se), and invasion of adjacent structures (si).

Figure 1 Survival of CRC patients with high and low MMP7 expression. (A) The survival time of CRC patients with high MMP7 expression was significantly shorter than that of patients with low MMP7 expression. Comparison of MMP7 expression (B) and patients’ survival according to their response to chemotherapy (sensitive or resistant) (C) *P<0.05.

Figure 2 Serum MMP7 levels acts as predictors of chemotherapy resistant CRC after FOLFOX4 treatment.

Table 3 Logistic Regression Analysis of Factors Affecting the Overall Survival of CRC Patients

Item	B	S.E.	Wals	Sig.	Exp (B)	95% CI of EXP (B)
Age	0.616	0.428	2.319	0.146	1.830	0.935	2.360
Gender	0.237	0.256	1.829	0.379	1.125	0.629	1.904
High MMP7	3.67	0.75	29.06	0.000	18.67	5.234	47.23
Tumor size >21 mm	−1.675	0.648	8.279	0.006	0.351	0.034	0.783
TNM stages III+IV	−1.782	0.528	7.369	0.004	0.562	0.024	0.827
Depth of tumor invasion	0.135	0.519	9.148	0.016	1.005	0.318	4.038
Lymph node metastasis	−0.324	0.539	0.419	0.429	0.739	0.183	2.185
Constant	−0.217	1.482	0.03	0.918	0.811	-	-