The Clinical Usefulness of Mean Corpuscular Hemoglobin Concentration in Patients with Pneumoconiosis

Figures & data

Table 1 The Characteristics in Patients with Different Stage Pneumoconiosis

	I/II Stage	III Stage	p value
Male (n, %)	20 (95.2)	29 (93.5)	1.000
Age (years)	50±10	52±8	0.408
Body mass index (kg/m^2)	22.6±2.1	21.4±2.8	0.101
Smoking history (n, %)	10 (47.6)	20 (64.5)	0.226
Pulmonary tuberculosis history (n, %)	6 (28.6)	10 (32.3)	0.777
Red blood cell (10^12/L)	4.72 (4.41–5.25)	4.73 (4.43–5.03)	0.970
Hemoglobin (g/L)	141 (132–155)	137 (128–148)	0.225
Hematocrit (%)	41.8 (39.8–47.0)	41.9 (39.8–44.6)	0.538
Mean corpuscular volume (fL)	89.7 (86.0–92.3)	89.3 (86.6–91.8)	0.896
Mean corpuscular hemoglobin (pg)	29.8 (28.4–30.6)	28.8 (27.0–30.5)	0.375
Mean corpuscular hemoglobin concentration (g/L)	331±9	324±12	0.024

Table 2 The Correlation Between MCHC and Continuous Parameters in Patients with Pneumoconiosis

	Correlation Coefficients	p value
Age	−0.149	0.292
Body mass index	0.349	0.011
Red blood cell	0.055	0.698
Hemoglobin	0.571	<0.001
Hematocrit	0.304	0.029
Mean corpuscular volume	0.164	0.245
Mean corpuscular hemoglobin	0.629	<0.001
Disease stage	−0.298	0.032

Table 3 The Multiple Linear Regression Analysis Associated with MCHC in Patients with Pneumoconiosis

	Univariate Analysis			Multivariate Analysis
	β	95% CI	p value	β	95% CI	p value
Gender	6.762	−0.606–20.129	0.315	−0.917	−2.271–0.438	0.179
Age	−0.184	−0.531–0.163	0.292	0.035	−0.001–0.072	0.058
Body mass index	1.512	0.358–2.666	0.011	−0.069	−0.196–0.057	0.276
Smoking history	4.085	−2.182–10.352	0.196	0.433	−0.226–1.092	0.192
Pulmonary tuberculosis history	−0.778	−7.597–6.041	0.820	−0.321	−0.988–0.347	0.338
Hemoglobin	0.390	0.241–0.539	<0.001	2.332	2.242–2.423	<0.001
Hematocrit	0.903	0.264–1.541	0.007	−7.423	−7.743– −7.104	<0.001
Mean corpuscular hemoglobin	2.452	1.496–3.408	<0.001	0.017	−0.125–0.159	0.812
Disease stage (I/II stage vs III stage)	−7.045	−13.142– −0.947	0.024	−0.853	−1.499- −0.206	0.011

Abbreviation: β, Unstandardized coefficients.

Table 4 The Logistic Regression Analysis Associated with Advanced Pneumoconiosis Patients

Variables	Univariate Analysis		Multivariate Analysis
	OR (CI95%)	p value	OR (CI95%)	p value
Gender	0.725 (0.062–8.547)	0.798	0.616 (0.036–10.426)	0.737
Age	1.028 (0.964–1.096)	0.402	1.010 (0.941–1.084)	0.783
Body mass index	0.825 (0.653–1.041)	0.105	0.899 (0.688–1.174)	0.434
Smoking history	2.000 (0.647–6.185)	0.229	3.108 (0.798–12.109)	0.102
Pulmonary tuberculosis history	1.190 (0.355–3.991)	0.778	0.904 (0.233–3.505)	0.884
Mean corpuscular hemoglobin concentration	0.940 (0.888–0.994)	0.031	0.936 (0.877–0.999)	0.046

Note: Dependent variable: I/II stage vs III stage.

Figure 1 Receiver operating characteristic curve of MCHC to identify advanced pneumoconiosis in patients with pneumoconiosis.