Expressions of Peptidoglycan Recognition Protein 1, Neuron Towards Axon Guidance Factor-1 and miR-142-3p and Their Correlations in Patients with Rheumatoid Arthritis

Figures & data

Table 1 General Data of the Three Groups

General Data	Control Group	Osteoarthritis Group	Rheumatoid Group	F/x^2	P
Sex (M/F)	15/15	17/13	33/27	0.298	0.903
Age (year)	46.35±10.23	45.51±9.88	47.16±10.52	1.132	0.260
BMI (kg/m^2)	23.05±2.16	23.51±2.37	23.26±2.25	0.153	0.696
Smoking history	13/17	14/16	28/32	0.103	0.951
Drinking history	12/18	13/17	26/34	0.099	0.950
Hypertension	14/16	12/18	25/35	0.312	0.858
Coronary heart disease	11/19	10/20	21/39	0.073	0.964

Table 2 Expressions of PGLYRP-1, Netrin-1 and miR-142-3p in Different Subjects

Subject	n	PGLYRP-1 (pg/mL)	Netrin-1	miR-142-3p
Control group	30	38.67±4.32	1.05±0.13	1.12±0.15
Osteoarthritis group	30	59.68±5.21*	0.86±0.09*	1.36±0.21*
Rheumatoid group	60	137.52±12.66*^#	0.35±0.04*^#	2.15±0.34*^#
F		46.710	42.540	16.245
P		0.001	0.001	0.001

Notes: *P<0.05 vs control group, ^#P<0.05 vs osteoarthritis group. Continuous variables are reported as mean ± SD.

Table 3 Correlations of PGLYRP-1, Netrin-1 and miR-142-3p Expressions with Clinical Characteristics of Patients with Rheumatoid Arthritis

Clinical Characteristic	n	PGLYRP-1 (pg/mL)	Netrin-1	miR-142-3p
X-Ray stage
Stage I–II	32	119.37±10.98	0.45±0.05	1.96±0.29
Stage III	28	151.63±14.19	0.23±0.03	2.32±0.41
t		9.912	20.290	3.963
P		0.001	0.001	0.001
Disease activity
Remission stage	35	118.69±11.21	0.46±0.06	1.94±0.28
Active stage	25	153.28±15.06	0.24±0.04	2.36±0.42
t		10.210	15.960	4.650
P		0.001	0.001	0.001
Joint deformity
No	38	117.29±10.75	0.47±0.05	1.95±0.31
Yes	22	154.40±14.68	0.22±0.02	2.34±0.39
t		11.240	22.370	4.267
P		0.001	0.001	0.001
Prognosis
Good	40	114.31±10.90	0.48±0.04	1.93±0.27
Poor	20	156.32±14.72	0.21±0.02	2.35±0.40
t		12.490	28.380	4.815
P		0.001	0.001	0.001

Notes: Continuous variables are reported as mean ± SD.

Figure 1 Correlations among PGLYRP-1, Netrin-1 and miR-142-3p expressions in patients with rheumatoid arthritis.

Table 4 Predictive Values of PGLYRP-1, Netrin-1 and miR-142-3p for the Prognosis of Patients with Rheumatoid Arthritis

Indicator	AUC	P	Sensitivity (%)	Specificity (%)	95% CI
PGLYRP-1	0.671	0.023	69.13	85.12	0.535–0.808
Netrin-1	0.683	0.015	68.43	83.37	0.546–0.821
miR-142-3p	0.679	0.017	68.51	83.55	0.544–0.814
Combination	0.803	0.001	83.27	72.29	0.695–0.911

Figure 2 ROC curves for predictive values of PGLYRP-1, Netrin-1, and miR-142-3p for the prognosis of patients with rheumatoid arthritis.