Systemic Immune-Inflammation and Systemic Inflammation Response Indices are Predictive Markers of Mortality in Inpatients Internal Medicine Services

Figures & data

Table 1 Baseline Characteristics of Patients

	Survivor	Ex	P value
Age, years	52.1±18.6	71.5±13.1	<0.001
Gender
Female, n (%)	702 (%60.9)	451 (%39.1)	0.019
Male, n (%)	596 (%56)	469 (%44)
Diabetes Mellitus, n (%)	427 (%52.3)	389 (%47.7)	<0.001
Hypertension, n (%)	548 (%49)	571 (%51)	<0.001
Coronary Artery Disease, n (%)	267 (%44.8)	329 (%55.2)	<0.001
Chronic Kidney Disease, n(%)	174 (%37.7)	288 (%62.3)	<0.001
Malignancy, n(%)	41 (%17.9)	188 (%82.1)	<0.001
White blood cell count, ×10^9/L	8.3 ± 3.7	9.4 ± 4.6	<0.001
Neutrophils, ×10^9/L	5.8 ± 3.5	7.3 ± 4.3	<0.001
Lymphocytes, ×10^9/L	1.6 ± 0.7	1.2 ± 0.6	<0.001
Monocytes, ×10^9/L	0.6 ± 0.3	0.7 ± 0.4	<0.001
Hemoglobin (g/dL)	10.9 ± 2.3	10 ± 2.3	<0.001
Hematocrit (%)	32.4 ± 7.2	30 ± 6.7	<0.001
Platelet (×1000/mm^3)	247.2 ± 89.9	249.3 ± 99.8	0.59
Hs-CRP (mg/L)	43 ± 72.6	74.7 ± 81.4	<0.001
Albumin (g/dL)	3.5 ± 0.5	3 ± 0.6	<0.001
Systemic Inflammation Response Index Quartile 1	433 (%78.2)	121 (%21.8)
Systemic Inflammation Response Index Quartile 2	372 (%67)	183 (%33)	<0.001
Systemic Inflammation Response Index Quartile 3	261 (%47)	294 (%53)
Systemic Inflammation Response Index Quartile 4	232 (%41.9)	322 (%58.1)
Systemic Immune Inflammation Index Quartile 1	428 (%77.3)	126 (%22.7)
Systemic Immune Inflammation Index Quartile 2	374 (%67.4)	181 (%32.6)	<0.001
Systemic Immune Inflammation Index Quartile 3	282 (%50.8)	237 (%49.2)
Systemic Immune Inflammation Index Quartile 4	214 (%38.6)	340 (%61.4)

Note: Statistically significant variables (p<0.05).

Abbreviation: CRP, C reactive protein.

Figure 1 Flow chart for patients’ selection.

Table 2 Cox Regression Analysis for Systemic Immune Inflammation Index

	95% CI	P value
Age	1.04 (1.03–1,0.05)	<0.001
Systemic Immune Inflammation Index		<0.001
Systemic Immune Inflammation Index (Quartile 2 – Quartile 1)	1.41 (0.92–2.16)	0.11
Systemic Immune Inflammation Index (Quartile 3 – Quartile 1)	1.72 (1.14–2.60)	0.01
Systemic Immune Inflammation Index (Quartile 4 – Quartile 1)	2.41 (1.62–3.57)	<0.001
Chronic Kidney Disease	1.66 (1.29–2.13)	<0.001
Malignancy	3.15 (2.36–4.21)	<0.001

Note: Statistically significant variables (p<0.05).

Table 3 Cox Regression Analysis for Systemic Inflammation Response Index

	95% CI	P value
Age	1.04 (1.03–1.05)	<0.001
Systemic Inflammation Response Index		<0.001
Systemic Inflammation Response Index (1. Quartile – 2. Quartile)	1.36 (0.90–2.07)	0.140
Systemic Inflammation Response Index (1. Quartile – 3. Quartile)	2.08 (1.40–3.07)	<0.001
Systemic Inflammation Response Index (1. Quartile – 4. Quartile)	2.02 (1.37–2.94)	<0.001
Chronic Kidney Disease	1.67 (1.29–2.15)	<0.001
Malignancy	3.40 (2.56–4.53)	<0.001

Note: Statistically significant variables (p<0.05).

Figure 2 Number of survivors and nonsurvivors according to SIRI’s quartiles.

Figure 3 Number of survivors and nonsurvivors according to SII’s quartiles.