The Evaluation of Serum Endocan, Interleukin-6, and CRP Levels Following Sleeve Gastrectomy

Figures & data

Table 1 The Demographical and Laboratory Features of Individuals with BMI ≥35 kg/m²

Age, Years	37.40±10.70
Sex, male/female, n	10/22
Smoker, yes/no	17/15
OSAS, yes/no	1/31
Comorbidity; n
No	11
DM	5
HT	6
IR	1
Other	9

Abbreviations: BMI, body mass index; BS, bariatric surgery; OSAS, obstructive sleep apnea syndrome; DM, diabetes mellitus; HT; hypertension; IR; insulin resistance.

Table 2 The Comparison of Pre and Postsurgical Metabolic and Inflammatory Parameters

	Before BS	After BS (3 Months)	P value	Reference Values
BMI, kg/m2	43.55±6.78	36.16±6.14	<0.001
Obesity, n
Class 1	–	15 (+2 Overweight)
Class 2	11	8
Class 3	21	7
HgbA1c, %	6.66±1.72	5.90±1.13	<0.001	<5.6%
Fasting insulin, mIU/L	31.16± 15.21	18.20±8.32	<0.001	2.6–24.9
HOMA -IR	5.76±1.96	2.99±0.89	<0.001	<1.9
IL-6, pg/mL	15.28±8.69	5.01±2.90	<0.001	NA*
Endocan, ng/mL	392.93±57.96	259.93±51.37	<0.001	NA*
Waist circle, cm	130.18±17.11	117.34±14.47	<0.001	<89 (female) <94 (male)
Hip circle, cm	139.31±16.87	128.75±16.15	<0.001
CRP, mg/L	7.211±5.14	4.39±3.49	0.006	0–5.0
Total cholesterol, mg/dl	227.78±45.88	192.07±26.82	<0.001	<200
LDL cholesterol, mg/dl	133.45±30.76	111.62±26.41	<0.001	<130
HDL cholesterol, mg/dl	44.00±8.32	51.55±9.90	<0.001	>40
Triglyceride, mg/dl	234.72±116.318	161.62±57.34	<0.001	<150
ALT, U/L	33.50±14.66	29.20±9.46	0.008	4–30

Notes: *There is no control group to establish reference L-6 and endocan values from pooled data in this study. So, the reference range for IL-6 and endocan is not available.

Abbreviations: BMI, body mass index; BS, bariatric surgery; HgbA1c, hemoglobin A1c; HOMA-IR, homeostatic model assessment insulin resistance; IL-6, interleukin-6; CRP, c-reactive protein; LDL, low-density lipoprotein; HDL, high-density lipoprotein; ALT, alanine transaminase.

Table 3 The Correlation Between the Laboratory Parameters and Pre- and Post-BS

	Pre-BS BMI		Post-BS BMI
	P value	R^2	P value	R^2
Endocan, ng/mL	0.007	0.221	<0.001	0.497
IL-6, pg/mL	<0.001	0.405	<0.001	0.528
HgbA1c, %	0.606	−0.009	0.685	−0.006
HOMA-IR	0.068	0.215	0.218	0.080
Fasting insulin, mIU/L	<0.001	0.422	<0.001	0.487
CRP, mg/dl	0.048	0.142	<0.001	0.353
Waist circle, cm	<0.001	0.553	<0.001	0.362
Hip circle, cm	<0.001	0.529	<0.001	0.425
Total cholesterol, mg/dl	0.039	0.123	0.031	0.147
LDL cholesterol, mg/dl	<0.001	0.438	0.006	0.226
HDL cholesterol, mg/dl	0.012	−0.193	0.001	−0.179
Triglyceride, mg/dl	0.002	0.277	<0.001	0.455
ALT, U/L	<0.001	0.555	<0.001	0.443

Abbreviations: BMI, body mass index; BS, bariatric surgery; HgbA1c, hemoglobin A1c; HOMA-IR, homeostatic model assessment insulin resistance; IL-6, interleukin-6; CRP, c-reactive protein; LDL, low-density lipoprotein; HDL, high-density lipoprotein; ALT, alanine transaminase.