An Energy-Efficient Test and Predictive Model for Recurrence After Radiotherapy in Localized Intermediate and Advanced Cervical Cancer Were Created Using Thymidine Kinase 1 in Conjunction with Inflammatory Markers and Tumor Markers

Figures & data

Figure 1 Working characterization curves of subjects with NLR, PLR, LMR and SII, TK1 levels before radiotherapy for diagnosing prognosis of cervical cancer after radiotherapy in patients with cervical cancer.

Abbreviations: NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; LMR, lymphocyte-to-monocyte ratio; SII, systemic immunoinflammatory index.

Table 1 Results of Univariate and Multivariate Analysis

Classification	Non-Recurrence Group (N=98)	Univariate Analysis		Multivariate Analysis
		p	95% CI	HR	p	95% CI
Age		0.20	−9.80–2.06
<50	32
≥50	66
Tissue Typing		0.70	−0.12–0.18
SC	89
NSC	9
Stage		0.19	−0.09–0.44
II	48
III+IVA	50
SCC		0.04	−28.09--0.71	1.04	0.01	1.01–1.07
<40ng/mL	63
≥40ng/mL	35
Calibre		0.85	−12.81–10.51
<40mm	52
≥40mm	46
Neutrophils (10^9/L)		0.37	−2.21--0.83
2~7.5	78
<4or>7.5	20
Leucocyte (10^9/L)		0.41	−2.32–0.96
4~10	78
<4or>10	20
Lymphocytes (10^9/L)		0.50	−0.21–0.42
0.84
<0.8or>4
Platelets (10^9/L)		0.95	−41.95–44.77
100~300	80
<100or>300	18
Hemoglobin (10^9g/L)		0.99	−37.75–38.25
110~150	59
<110or>150	39
Monocytes (10^9/L)		0.69	−37.17–56.01
0.16~1.2	88
<0.16or>1.2	10
NLR		0.93	−5.86–6.45
<5.57	87
≥5.57	11
PLR		0.71	−352.92–517.65
<198.00	82
≥198.00	16
LMR		0.42	−2.11–5.05
<4.19	49
≥4.19	49
SII		0.02	−3446.73--72.88	1.00	0.14	1.00–1.00
<707.88	71
≥707.88	27
TK1		0.02	−1.78--0.46	1.57	0.02	1.00–1.00
<1.02	54
≥1.02	44

Abbreviations: NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; LMR, lymphocyte-to-monocyte ratio; SII, systemic immunoinflammatory index; SC, Squamous Carcinoma; NSC, Non-squamous; SCC, squamous cell antigen.

Table 2 Probability of Recurrence Predicted by the Recurrence Model After Radiotherapy for Cervical Cancer

Classification	Predicted Non-Recurrence	Predicted Recurrence	Total	Predictive probability
Actual non-recurrence	96	2	98	97.96
Actual recurrence	13	3	16	18.75
Total	109	5	114	86.84

Figure 2 Nomogram prediction model for recurrence after radiotherapy for cervical cancer. **:P<0.05.

Abbreviations: SCC, squamous cell antigen; TK1, thymidine kinase 1; Pr(RE), probability of recurrence.

Figure 3 ROC curve of radiotherapy recurrence prediction model for cervical cancer.

Figure 4 Calibration curve of the recurrence prediction model after radiotherapy for cervical cancer.

Figure 5 Cervical cancer radiotherapy recurrence prediction model and DCA curve for TNM and SCC prediction.

Figure 6 CIC curve of radiotherapy recurrence prediction model for cervical cancer.