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Hematology

Value of Absolute Eosinophil Count in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

, , , , , & ORCID Icon show all
Pages 1025-1038 | Received 27 Nov 2023, Accepted 26 Feb 2024, Published online: 18 Mar 2024

Figures & data

Figure 1 Flow chart.

Abbreviations: ACS, acute coronary syndrome; PCI, percutaneous coronary intervention; CABG, Coronary Artery Bypass Grafting; MACCEs, major adverse cardiovascular and cerebrovascular events; AEC, absolute eosinophil count.
Figure 1 Flow chart.

Table 1 Baseline Clinical and Laboratory Characteristics of the Study Patients According to the AEC Tertiles

Table 2 Discharge Medications, Angiographic Findings and Procedural Results of the Study Patients According to the AEC Index Tertiles

Table 3 Adverse Cardiovascular Events According to AEC Tertiles During Follow-Up

Figure 2 The AEC index and risk: Kaplan–Meier curves for the incidences of the primary endpoint (a), cardiovascular death (b), non-fatal stroke (c), non-fatal myocardial infarction (d) among the 3 study groups based on the AEC index tertiles.

Figure 2 The AEC index and risk: Kaplan–Meier curves for the incidences of the primary endpoint (a), cardiovascular death (b), non-fatal stroke (c), non-fatal myocardial infarction (d) among the 3 study groups based on the AEC index tertiles.

Table 4 Relationship Between the Incidence of the Primary Endpoint and the AEC Index Expressed as a Categorical Variable

Figure 3 Risk of cardiovascular death, non-fatal stroke or non-fatal myocardial infarction, according to tertiles of the AEC index. Error bars indicate 95% confidence intervals. The first tertile is the reference. (a) Univariate relationship. (b) Relationship adjusted for age, sex, SYNTAX II score, hs-CRP, never smoking, hypertension, diabetes, presence of cardiac failure, PAD, past PCI, previous MI and complete revascularization.

Figure 3 Risk of cardiovascular death, non-fatal stroke or non-fatal myocardial infarction, according to tertiles of the AEC index. Error bars indicate 95% confidence intervals. The first tertile is the reference. (a) Univariate relationship. (b) Relationship adjusted for age, sex, SYNTAX II score, hs-CRP, never smoking, hypertension, diabetes, presence of cardiac failure, PAD, past PCI, previous MI and complete revascularization.

Table 5 Relationship Between the Incidence of the Primary Endpoint and Comorbidities, Medicines and ACS Subtypes

Figure 4 ROC analysis showing the cut-off values of AEC (A), SYNTAX II score (B) and the adjustment of SYNTAX II Score by AEC (C) to predict the primary endpoint. The primary endpoint was defined as a composite of cardiovascular death, no-fatal MI or stroke, and the individual components of them.

Abbreviations: ROC, receiver operating curve; AEC, absolute eosinophil count; AUC, area under the curve; MI, myocardial infarction.
Figure 4 ROC analysis showing the cut-off values of AEC (A), SYNTAX II score (B) and the adjustment of SYNTAX II Score by AEC (C) to predict the primary endpoint. The primary endpoint was defined as a composite of cardiovascular death, no-fatal MI or stroke, and the individual components of them.

Data Sharing Statement

The unadjusted data that underlies the findings of this article will be accessible by the authors, free from any undue constraints.