Intraoperative Dexmedetomidine for Prevention of Postoperative Cognitive Dysfunction and Delirium in Elderly Patients with Lobectomy: A Propensity Score-Matched, Retrospective Study

Figures & data

Table 1 Baseline Characteristics in Both Groups

	Dexmedetomidine group (n=87)	Control group (n=87)	P value
Age, yrs	69.7±1.9	69.1±2.1	0.06
Male, n (%)	62 (71.3%)	57 (65.5%)	0.42
BMI, kg/m^2	22.5±1.0	22.5±0.8	1.00
Education			0.65
Primary school or below	44 (50.6%)	38 (43.7%)
Secondary school	27 (31.0%)	30 (34.5%)
High school or above	16 (18.4%)	19 (21.8%)
ASA, n (%)			0.65
Grade I	51 (58.6%)	48 (55.2%)
Grade II	36 (41.4%)	39 (44.8%)
Histology, n (%)
Adenocarcinoma	55 (63.2%)	60 (69.0%)	0.42
Squamous	32 (36.8%)	27 (31.0%)
Operation time, min	126.9±3.9	126.9±4.2	0.96
Anesthesia time. min	164.1±11.6	162.8±11.6	0.48

Abbreviations: BMI, body mass index; ASA, American Society of Anesthesiologists.

Table 2 Comparison of Hemodynamic Parameters at Baseline and After Regaining Consciousness Between Two Groups

	Dexmedetomidine group (n=87)	Control group (n=87)	P value
MAP, mmHg
Baseline	95.3±3.4	95.3±3.2	0.93
After regaining consciousness	93.7±3.8	93.5±3.7	0.68
HR, beats/min
Baseline	81.3±3.5	80.8±3.3	0.35
After regaining consciousness	79.0±3.5	78.9±3.9	0.82
CVP, cm H2O
Baseline	6.4±0.2	6.4±0.2	0.83
After regaining consciousness	7.2±0.2	7.2±0.2	0.50

Abbreviations: MAPM mean arterial pressure; HR, heart rate; CVP, central venous pressure.

Figure 1 Comparison of (A) Montreal Cognitive Assessment (MoCA) scores and (B) incidence of delirium between the two groups. * P<0.05 compared with control group.

Figure 2 Comparison of (A) S100β, (B) TNF-α, and (C) IL-6 between the two groups on the day before operation and the 1^st, 3^rd, and 7^th postoperative days. * P<0.05 compared with control group.

Table 3 Comparison of Adverse Events Between Two Groups

	Dexmedetomidine group (n=87)	Control group (n=87)	P value
Bradycardia	9 (10.3%)	8 (9.2%)	0.80
Nausea	8 (9.2%)	7 (8.0%)	0.79
Vomiting	4 (4.6%)	3 (3.4%)	0.70
Hypotension	6 (6.9%)	4 (4.6%)	0.52
Bleeding	1 (1.1%)	2 (2.3%)	1.00
Infections	1 (1.1%)	1 (1.1%)	1.00

Data Sharing Statement

The datasets generated and/or analyzed during the current study are not publicly available as it could compromise the privacy of research participants, but are available from the corresponding author on reasonable request.