Burden of disease from atrial fibrillation in adults from seven countries in Latin America

Figures & data

Figure 1 Article flow for the systematic literature review.

Table 1 Total AF prevalence (cases, %) in seven Latin American countries, by age groupa

Age group (year)	Argentina	Brazil	Chile	Colombia	Mexico	Peru	Venezuela
40–49	18,573 (0.40%)	103,203 (0.41%)	10,029 (0.40%)	22,970 (0.40%)	59,637 (0.43%)	13,625 (0.41%)	14,104 (0.41%)
50–59	28,054 (0.71%)	134,117 (0.72%)	13,793 (0.72%)	29,699 (0.72%)	70,332 (0.75%)	16,480 (0.72%)	17,750 (0.72%)
60–69	65,573 (2.22%)	247,364 (2.26%)	27,246 (2.25%)	55,581 (2.26%)	128,498 (2.34%)	32,034 (2.24%)	34,430 (2.28%)
70–79	91,639 (4.78%)	271,939 (4.90%)	33,277 (4.86%)	70,250 (4.94%)	148,795 (5.10%)	40,041 (4.90%)	36,766 (4.89%)
≥80	77,509 (8.17%)	143,662 (8.26%)	26,257 (8.26%)	48,467 (8.17%)	114,745 (8.48%)	23,935 (8.31%)	21,354 (8.33%)
All population ≥40	281,348 (1.95%)	900,285 (1.44%)	110,602 (1.68%)	226,967 (1.59%)	522,007 (1.58%)	126,115 (1.55%)	124,404 (1.47%)

Note:

a Estimated from national demographic data and international literature.

Abbreviation: AF, atrial fibrillation.

Table 2 AF cases in seven Latin American countries, by age group, sex, comorbidity, type of AF, and inpatient statusa

Cases	Argentina	Brazil	Chile	Colombia	Mexico	Peru	Venezuela
Total (% of estimated prevalence)	145,557 (51.7%)	480,108 (53.3%)	58,471 (52.9%)	118,724 (52.3%)	279,747 (53.6%)	67,496 (53.5%)	66,066 (53.1%)
By age group, year (% of estimated prevalence)
40–49	11,285 (60.8%)	62,643 (60.7%)	6,145 (61.3%)	13,863 (60.4%)	36,767 (61.7%)	8,374 (61.5%)	8,539 (60.5%)
50–59	15,626 (55.7%)	74,623 (55.6%)	7,747 (56.2%)	16,431 (55.3%)	39,747 (56.5%)	9,285 (56.3%)	9,851 (55.5%)
60–69	37,851 (57.7%)	142,639 (57.7%)	15,860 (58.2%)	31,867 (57.3%)	75,260 (58.6%)	18,705 (58.4%)	19,802 (57.5%)
70–79	45,473 (49.6%)	134,802 (49.6%)	16,652 (50.0%)	34,625 (49.3%)	74,916 (50.4%)	20,099 (50.2%)	18,178 (49.4%)
≥80	35,322 (45.6%)	65,401 (45.5%)	12,067 (46.0%)	21,938 (45.3%)	53,057 (46.2%)	11,033 (46.1%)	9,696 (45.4%)
By sex (% of total treated)
Male	83,850 (57.6%)	274,816 (57.2%)	33,541 (40.0%)	67,994 (57.3%)	159,235 (56.9%)	38,542 (57.1%)	37,617 (56.9%)
Female	61,707 (42.4%)	205,292 (42.8%)	24,930 (60.0%)	50,730 (42.7%)	120,512 (43.1%)	28,954 (42.9%)	28,449 (43.1%)
By comorbidityb (% of total treated)
Hypertension	82,240 (56.5%)	249,656 (52.0%)	33,328 (57.0%)	60,549 (51.0%)	153,861 (55.0%)	36,785 (54.5%)	35,676 (54.0%)
Diabetes	38,281 (26.3%)	76,817 (16.0%)	8,771 (15.0%)	26,119 (22.0%)	78,329 (28.0%)	24,636 (36.5%)	7,928 (12.0%)
Heart failure	43,667 (30.0%)	96,022 (20.0%)	17,541 (30.0%)	28,494 (24.0%)	83,924 (30.0%)	9,787 (14.5%)	15,195 (23.0%)
Stroke	18,486 (12.7%)	43,210 (9.0%)	3,508 (6.0%)	8,311 (7.0%)	27,975 (10.0%)	8,100 (12.0%)	1,982 (3.0%)
By type of AF (% of total treated)
NVAF	125,342 (86.1%)	412,407 (85.9%)	50,391 (86.2%)	102,043 (86.0%)	240,528 (86.0%)	57,991 (85.9%)	56,366 (85.3%)
VAF	20,215 (13.9%)	67,701 (14.1%)	8,080 (13.8%)	16,681 (14.1%)	39,219 (14.0%)	9,505 (14.1%)	9,700 (14.7%)
By inpatient status (% of total treated)	57,930 (39.8%)	190,879 (39.8%)	23,467 (40.1%)	46,933 (39.5%)	112,967 (40.4%)	27,013 (40.0%)	25,718 (38.9%)

Notes:

a Data from patients diagnosed and treated in the respective national health care systems

b some patients may have had more than one comorbidity.

Abbreviations: AF, atrial fibrillation; NVAF, nonvalvular atrial fibrillation; VAF, valvular atrial fibrillation.

Table 3 Inpatient and outpatient treatments used for AF, by country

	Argentina	Brazil	Chile	Colombia	Mexico	Peru	Venezuela
Outpatients
No treatment	35,807 (24.6%)	87,860 (18.3%)	12,396 (21.2%)	26,594 (22.4%)	62,943 (22.5%)	14,417 (21.4%)	13,411 (20.3%)
VKA	77,727 (53.4%)	279,423 (58.2%)	30,580 (52.3%)	53,663 (45.2%)	157,218 (56.2%)	37,933 (56.2%)	38,014 (57.5%)
VKA + ASA	18,340 (12.6%)	84,499 (17.6%)	11,870 (20.3%)	33,955 (28.6%)	46,438 (16.6%)	10,597 (15.7%)	8,325 (12.6%)
VKA + ASA + antiplatelets	13,682 (9.4%)	28,326 (5.9%)	3,625 (6.2%)	4,512 (3.8%)	13,148 (4.7%)	4,549 (6.7%)	6,316 (9.6%)
Inpatients
UFH	38,002 (65.6%)	102,941 (53.9%)	13,172 (56.1%)	29,676 (63.2%)	69,249 (61.3%)	14,709 (54.5%)	15,760 (61.3%)
LMWH	15,641 (27.0%)	70,740 (37.1%)	8,300 (35.4%)	12,470 (26.6%)	31,970 (28.3%)	9,792 (36.3%)	7,515 (29.2%)
VKA	4,287 (7.4%)	17,198 (9.0%)	1,995 (8.5%)	4,787 (10.2%)	11,749 (10.4%)	2,512 (9.3%)	2,443 (9.5%)

Abbreviations: ASA, acetylsalicylic acid; LMWH, low-molecular-weight heparin; UFH, unfractionated heparin; VKA, vitamin K antagonist.