Systemic inflammatory response syndrome and platelet count ≥250×10⁹ are associated with venous thromboembolic disease

Figures & data

Table 1 Characteristics of patients with and without SIRS

	Overall sample (n=884)	SIRS present (n=203)	SIRS absent (n=681)	P-value
Mean platelet count (×10^9)	254.6±8.1	278.7±21.6	247.4±8.2	0.001
Platelet count ≥250×10^9	44%	48.3%	42.7%	NS
VTE	23%	36.5%	22.8%	<0.001
Mean temperature (°F)	98.7±1.9	98.4±0.2	98.9±2.6	NS
Mean heart rate (bpm)	82.3±1.1	98.1±2.1	77.5±1.1	<0.001
Mean respiratory rate (bpm)	19.4±0.2	21.1±0.5	18.9±0.2	<0.001
Mean WBC count (×10^9/L)	10.4±0.4	15.8±1.4	8.7±0.3	<0.001

Abbreviations: NS, not significant; SIRS, systemic inflammatory response syndrome; VTE, venous thromboembolism; WBC, white blood cell.

Figure 1 Comparison of subjects with and without VTE as determined by venous duplex and CTPA.

Note: Thrombocytosis (platelet count ≥250×10⁹/L) and SIRS were positively associated with VTE and mean platelet count was significantly higher in these patients (P<0.001).
Abbreviations: CTPA, computed tomography pulmonary angiogram; SIRS, systemic inflammatory response syndrome; VTE, venous thromboembolism.

Table 2 Characteristics of patients with and without VTE

	Overall sample (n=884)	VTE present (n=229)	VTE absent (n=655)	P-value
Mean platelet count (×10^9)	254.6±8.1	291.5±18.8	241.7±8.5	<0.001
Platelet count ≥250×10^9	44%	53.7%	40.6%	<0.001
SIRS	23%	32.3%	19.7%	<0.001
Mean temperature (°F)	98.7±1.9	101.3±7.6	97.9±0.1	NS
Mean heart rate (bpm)	82.3±1.1	83.8±2	81.8±1.3	NS
Mean respiratory rate (bpm)	19.4±0.2	19.7±0.4	19.3±0.2	NS
Mean WBC count (×10^9/L)	10.4±0.4	10.6±0.8	10.3±0.5	NS

Abbreviations: NS, not significant; SIRS, systemic inflammatory response syndrome; VTE, venous thromboembolism; WBC, white blood cell.