Advanced search
Publication Cover
International Journal of Nanomedicine Volume 11, 2016 - Issue
Submit an article Journal homepage
392
Views
115
CrossRef citations to date
0
Altmetric
Review

Lipid nanoparticles for targeted siRNA delivery – going from bench to bedside

Timofei S Zatsepin1 Center of Functional Genomics, Skolkovo Institute of Science and Technology;2 Department of Chemistry, Lomonosov Moscow State University;3 Production Department, Central Research Institute of Epidemiology, Moscow, Russia
,
Yuri V Kotelevtsev1 Center of Functional Genomics, Skolkovo Institute of Science and Technology
&
Victor Koteliansky1 Center of Functional Genomics, Skolkovo Institute of Science and Technology;2 Department of Chemistry, Lomonosov Moscow State UniversityCorrespondence[email protected]
Pages 3077-3086 | Published online: 05 Jul 2016

Figures & data

Figure 1 Structures of lipids used for RNA delivery.

Notes: (A) Cationic lipids and lipidoids. (B) Phospholipids. (C) PEG lipids, cholesterol.

Abbreviations: DOPC, 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine; PEG, polyethylene glycol; DOTAP, 1,2-dioleoyl-3-trimethylammonium-propane; DSPC, 1,2-distearoyl-sn-glycero-3-phosphocholine; PEG-C-DMA, 3-N-[(ω-methoxypoly(ethylene glycol)2000)carbamoyl]-1,2-dimyristyloxy-propylamine; mPEG-DSPE, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000].

Figure 1 Structures of lipids used for RNA delivery.Notes: (A) Cationic lipids and lipidoids. (B) Phospholipids. (C) PEG lipids, cholesterol.Abbreviations: DOPC, 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine; PEG, polyethylene glycol; DOTAP, 1,2-dioleoyl-3-trimethylammonium-propane; DSPC, 1,2-distearoyl-sn-glycero-3-phosphocholine; PEG-C-DMA, 3-N-[(ω-methoxypoly(ethylene glycol)2000)carbamoyl]-1,2-dimyristyloxy-propylamine; mPEG-DSPE, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000].

Figure 2 Schematic structure of lipid nanoparticles.

Abbreviation: PEG, polyethylene glycol.

Figure 2 Schematic structure of lipid nanoparticles.Abbreviation: PEG, polyethylene glycol.

Figure 3 Structures of modified RNA.

Figure 3 Structures of modified RNA.

Table 1 Selected clinical trials of siRNA and antisense oligonucleotides

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.