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Original Research

Andrographolide nanoparticles in leishmaniasis: characterization and in vitro evaluations

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Pages 1113-1121 | Published online: 09 Dec 2010

Figures & data

Table 1 Characterization of AGnp preparations

Figure 1 Andrographolide (AG) and andrographolide nanoparticles (AGnp) in water medium. A) AG flakes insoluble in water. B) AGnp (Formulation B) colloid in water.

Figure 1 Andrographolide (AG) and andrographolide nanoparticles (AGnp) in water medium. A) AG flakes insoluble in water. B) AGnp (Formulation B) colloid in water.

Figure 2 Atomic force microscopy study of andrographolide nanoparticles. A) Single particle 3D surface topography. B) 2D study of particle distribution (Formulation B).

Figure 2 Atomic force microscopy study of andrographolide nanoparticles. A) Single particle 3D surface topography. B) 2D study of particle distribution (Formulation B).

Figure 3 A) Fourier transform infrared overlay of entire region. B) Overlay at C—OH region. C) Overlay at C—OH region and CH2 region. Color codes: andrographolide (AG), blue; polyvinyl alcohol/poly(DL-lactide-co-glycolic acid) (PVA/PLGA), brown; AG/PVA/PLGA, green.

Figure 3 A) Fourier transform infrared overlay of entire region. B) Overlay at C—OH region. C) Overlay at C—OH region and CH2 region. Color codes: andrographolide (AG), blue; polyvinyl alcohol/poly(DL-lactide-co-glycolic acid) (PVA/PLGA), brown; AG/PVA/PLGA, green.

Figure 4 In vitro release profile of andrographolide nanoparticle preparations. Results expressed as mean ± SD (n = 3).

Figure 4 In vitro release profile of andrographolide nanoparticle preparations. Results expressed as mean ± SD (n = 3).

Figure 5 Atomic force microscopy of andrographolide (AG) nanoparticles before and after dissolution. A) Formulation B before release. B) Formulation B, 600 hours after AG release.

Figure 5 Atomic force microscopy of andrographolide (AG) nanoparticles before and after dissolution. A) Formulation B before release. B) Formulation B, 600 hours after AG release.

Table 2 Korsemeyer–Peppas release kinetics modeling for AGnp

Figure 6 Andrographolide nanoparticles in macrophages under fluorescence microscope after 2 hours’ incubation.

Figure 6 Andrographolide nanoparticles in macrophages under fluorescence microscope after 2 hours’ incubation.

Table 3 Antileishmanial activity of AG, AGnp, and standard antileishmanial agents against L. donovani