Figures & data
Table 1 Characterization of AGnp preparations
Figure 1 Andrographolide (AG) and andrographolide nanoparticles (AGnp) in water medium. A) AG flakes insoluble in water. B) AGnp (Formulation B) colloid in water.
![Figure 1 Andrographolide (AG) and andrographolide nanoparticles (AGnp) in water medium. A) AG flakes insoluble in water. B) AGnp (Formulation B) colloid in water.](/cms/asset/08612456-a950-42ab-9fa9-96a1582253aa/dijn_a_12184788_f0001_c.jpg)
Figure 2 Atomic force microscopy study of andrographolide nanoparticles. A) Single particle 3D surface topography. B) 2D study of particle distribution (Formulation B).
![Figure 2 Atomic force microscopy study of andrographolide nanoparticles. A) Single particle 3D surface topography. B) 2D study of particle distribution (Formulation B).](/cms/asset/adcb2265-d7f7-4563-943f-e04b23e8d95a/dijn_a_12184788_f0002_c.jpg)
Figure 3 A) Fourier transform infrared overlay of entire region. B) Overlay at C—OH region. C) Overlay at C—OH region and CH2 region. Color codes: andrographolide (AG), blue; polyvinyl alcohol/poly(DL-lactide-co-glycolic acid) (PVA/PLGA), brown; AG/PVA/PLGA, green.
![Figure 3 A) Fourier transform infrared overlay of entire region. B) Overlay at C—OH region. C) Overlay at C—OH region and CH2 region. Color codes: andrographolide (AG), blue; polyvinyl alcohol/poly(DL-lactide-co-glycolic acid) (PVA/PLGA), brown; AG/PVA/PLGA, green.](/cms/asset/7445636a-1c34-4a06-8e19-39fdd7b4a307/dijn_a_12184788_f0003_c.jpg)
Figure 4 In vitro release profile of andrographolide nanoparticle preparations. Results expressed as mean ± SD (n = 3).
![Figure 4 In vitro release profile of andrographolide nanoparticle preparations. Results expressed as mean ± SD (n = 3).](/cms/asset/a71ffb87-dba5-4841-a786-6fe218c365bb/dijn_a_12184788_f0004_c.jpg)
Figure 5 Atomic force microscopy of andrographolide (AG) nanoparticles before and after dissolution. A) Formulation B before release. B) Formulation B, 600 hours after AG release.
![Figure 5 Atomic force microscopy of andrographolide (AG) nanoparticles before and after dissolution. A) Formulation B before release. B) Formulation B, 600 hours after AG release.](/cms/asset/772c9755-003f-40ca-9647-8a3a8366f551/dijn_a_12184788_f0005_c.jpg)
Table 2 Korsemeyer–Peppas release kinetics modeling for AGnp
Figure 6 Andrographolide nanoparticles in macrophages under fluorescence microscope after 2 hours’ incubation.
![Figure 6 Andrographolide nanoparticles in macrophages under fluorescence microscope after 2 hours’ incubation.](/cms/asset/18c2f7c3-6ef6-4830-aa9f-e18c470122da/dijn_a_12184788_f0006_c.jpg)
Table 3 Antileishmanial activity of AG, AGnp, and standard antileishmanial agents against L. donovani