Recent advances in PEG–PLA block copolymer nanoparticles

Figures & data

Figure 1 Synthesis scheme of mPEG–PLA.¹⁰

Copyright © 2010, Elsevier Limited. Reproduced with permission from Zhang X, Li Y, Chen X, et al. Synthesis and characterization of the paclitaxel/MPEG-PLA block copolymer conjugate. Biomaterials. 2005;26(14):2121–2128.

Abbreviations: mPEG, methoxy polyethylene glycol; PLA, polylactic acid.

Figure 2 Synthesis scheme of acetal-ended poly(ethylene glycol)–poly(lactic acid) copolymers.¹³

Copyright © 2010, American Chemical Society. Reproduced with permission from Otsuka H, Nagasaki Y, Kataoka K. Surface characterization of functionalized polylactide through the coating with heterobifunctional poly(ethylene glycol)/polylactide block copolymers. Biomacromolecules. 2000;1(1):39–48.

Figure 3 Classification of nanoparticle drug delivery systems and their general characteristics.¹⁸

Copyright © 2010, Elsevier Limited. Reproduced with permission from Letchford K, Burt H. A review of the formation and classification of amphiphilic block copolymer nanoparticulate structures: micelles, nanospheres, nanocapsules and polymersomes. Eur J Pharm Biopharm. 2007;65(3):259–269.

ZhangXLiYChenXSynthesis and characterization of the paclitaxel/MPEG-PLA block copolymer conjugateBiomaterials200526142121212815576187

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OtsukaHNagasakiYKataokaKSurface characterization of functionalized polylactide through the coating with heterobifunctional poly(ethylene glycol)/polylactide block copolymersBiomacromolecules200011394811709841

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LetchfordKBurtHA review of the formation and classification of amphiphilic block copolymer nanoparticulate structures: micelles, nanospheres, nanocapsules and polymersomesEur J Pharm Biopharm200765325926917196803

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