Cancer drug therapy and stochastic modeling of “nano-motors”

Figures & data

Figure 1 The positioning of Eg5 in a cell before cell division.

Figure 2 Kinesin-5 complex ([A] adapted from Park et al³⁹) for the preparation of (B) Ispinesib antitumor drug.

Figure 3 Drug therapy – theoretical strategy and the impact on drift.

Figure 4 The probability density function for the motor proteins in a normal cell.

Figure 5 The probability density function for the motor proteins in a tumor cell when no drug was injected.

Figure 6 States of motor protein inside a cancerous cell for lower dose of drug.

Figure 7 States of motor protein inside a cancerous cell for increased dose of drug.

Figure 8 States of motor protein of a treated cell, for enhanced drug dose; the straight line refers to no movement (ie, apoptosis).

ParkHWMaZZhuHJiangSRobinsonRCEndowSAStructural basis of small molecule ATPase inhibition of a human mitotic kinesin motor proteinSci Rep2017711512129123223

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