Figures & data
Figure 1 Schematic drawing of the induction heating unit.
Note: Three optical thermometers were used.
![Figure 1 Schematic drawing of the induction heating unit.Note: Three optical thermometers were used.](/cms/asset/106530a3-4461-4149-9665-42de5e7f00db/dijn_a_12194223_f0001_c.jpg)
Figure 2 The custom-made incubation system.
Notes: All the six double-sided walls of the incubator were heated by water recirculated by a thermostated bath. For WHT treatment, the CO2 supply of the homemade incubator was discontinued.
Abbreviation: WHT, water-based hyperthermia.
![Figure 2 The custom-made incubation system.Notes: All the six double-sided walls of the incubator were heated by water recirculated by a thermostated bath. For WHT treatment, the CO2 supply of the homemade incubator was discontinued.Abbreviation: WHT, water-based hyperthermia.](/cms/asset/a9c3a8e9-98ea-4d6b-aed4-54e527f445c4/dijn_a_12194223_f0002_c.jpg)
Figure 3 Cell viability after conventional hyperthermic treatment at different temperatures.
Note: In light-blue are MNP-free tumor cells, and in red tumor cells incubated with MNPs.
Abbreviation: MNP, magnetic nanoparticle.
![Figure 3 Cell viability after conventional hyperthermic treatment at different temperatures.Note: In light-blue are MNP-free tumor cells, and in red tumor cells incubated with MNPs.Abbreviation: MNP, magnetic nanoparticle.](/cms/asset/d7129b7d-81e2-4391-8b04-fd7c7d8203a1/dijn_a_12194223_f0003_c.jpg)
Figure 4 Tumor cells after WHT exposure.
Notes: (A) hOS cells at 37°C (control cells); (B–F) hOS cells subjected for one hour to WHT.
Abbreviation: WHT, water-based hyperthermia.
![Figure 4 Tumor cells after WHT exposure.Notes: (A) hOS cells at 37°C (control cells); (B–F) hOS cells subjected for one hour to WHT.Abbreviation: WHT, water-based hyperthermia.](/cms/asset/caba3abf-8b7c-4865-94ce-582411c10948/dijn_a_12194223_f0004_b.jpg)
Figure 5 Comparison between the two hyperthermic regimes: blue – WHT and red – MHT.
Abbreviations: MHT, magnetic hyperthermia; WHT, water-based hyperthermia.
![Figure 5 Comparison between the two hyperthermic regimes: blue – WHT and red – MHT.Abbreviations: MHT, magnetic hyperthermia; WHT, water-based hyperthermia.](/cms/asset/80c4b0c5-861e-4699-ad97-6597bf01f875/dijn_a_12194223_f0005_c.jpg)
Figure 6 (A) Schematic representation of tumor cells heated by MNPs placed in AMF (MHT case). Cells close to MNPs are subjected to a higher treatment temperature due to a high gradient temperature near MNPs; (B) tumor cells and MNPs heated uniformly by exogenous heat (WHT case). There is no temperature gradient near MNPs after equilibrium macroscopic temperature is established.
Abbreviations: AMF, alternating magnetic field; MHT, magnetic hyperthermia; MNP, magnetic nanoparticle; WHT, water-based hyperthermia.
![Figure 6 (A) Schematic representation of tumor cells heated by MNPs placed in AMF (MHT case). Cells close to MNPs are subjected to a higher treatment temperature due to a high gradient temperature near MNPs; (B) tumor cells and MNPs heated uniformly by exogenous heat (WHT case). There is no temperature gradient near MNPs after equilibrium macroscopic temperature is established.Abbreviations: AMF, alternating magnetic field; MHT, magnetic hyperthermia; MNP, magnetic nanoparticle; WHT, water-based hyperthermia.](/cms/asset/99f319bd-c3ac-43ec-a03f-dcacee60a0a8/dijn_a_12194223_f0006_c.jpg)