Figures & data
Figure 1 Schematic drawing of the induction heating unit.
Note: Three optical thermometers were used.
Figure 2 The custom-made incubation system.
Notes: All the six double-sided walls of the incubator were heated by water recirculated by a thermostated bath. For WHT treatment, the CO2 supply of the homemade incubator was discontinued.
Abbreviation: WHT, water-based hyperthermia.
Figure 3 Cell viability after conventional hyperthermic treatment at different temperatures.
Note: In light-blue are MNP-free tumor cells, and in red tumor cells incubated with MNPs.
Abbreviation: MNP, magnetic nanoparticle.
Figure 4 Tumor cells after WHT exposure.
Notes: (A) hOS cells at 37°C (control cells); (B–F) hOS cells subjected for one hour to WHT.
Abbreviation: WHT, water-based hyperthermia.
Figure 5 Comparison between the two hyperthermic regimes: blue – WHT and red – MHT.
Abbreviations: MHT, magnetic hyperthermia; WHT, water-based hyperthermia.
Figure 6 (A) Schematic representation of tumor cells heated by MNPs placed in AMF (MHT case). Cells close to MNPs are subjected to a higher treatment temperature due to a high gradient temperature near MNPs; (B) tumor cells and MNPs heated uniformly by exogenous heat (WHT case). There is no temperature gradient near MNPs after equilibrium macroscopic temperature is established.
Abbreviations: AMF, alternating magnetic field; MHT, magnetic hyperthermia; MNP, magnetic nanoparticle; WHT, water-based hyperthermia.
Figure 7 Temperature curves for WHT and MHT.
Notes: The heating rate for WHT was 0.26°C/s vs 0.028°C/s for MHT. The average heating rate for WHT was 0.082°C/s and 0.012°C/s for MHT.
Abbreviations: MHT, magnetic hyperthermia; MNPs, magnetic nanoparticles; WHT, water-based hyperthermia.
