Effect of interaction of magnetic nanoparticles of Fe₃O₄ and artesunate on apoptosis of K562 cells

Figures & data

Figure 1 The inhibition ratio of K562 treated with ART or the copolymer of ART with MNPs-Fe₃O₄ (100:1) for 48 hours.

Note: *P < 0.05, compared with the ART alone.

Abbreviations: MNPs-Fe₃O₄, magnetic nanoparticles of Fe₃O₄; ART, artesunate.

Figure 2 Effect of 1.0 μM MNPs-Fe₃O₄, 100 μM ART, and the copolymer of ART with MNPs-Fe₃O₄ (100:1) on the cell viability in the presence or absence of 40 μM Z-VAD-FMK for 48 hours.

Note: *P < 0.05, compared with the absence of Z-VAD-FMK.

Abbreviations: MNPs-Fe₃O₄, magnetic nanoparticles of Fe₃O₄; ART, artesunate.

Figure 3 Apoptosis of K562 cells treated with ART or the copolymer of ART with MNPs-Fe₃O₄ for 48 hours. A) Control; B) 1 μM MNPs-Fe₃O₄; C) 100 μM ART; D) the copolymer of 100 μM ART with 1 μM MNP-Fe₃O₄.

Abbreviations: MNPs-Fe₃O₄, magnetic nanoparticles of Fe₃O₄; ART, artesunate.

Figure 4 Apoptosis ratio of K562 cells treated with different concentrations of ART or the copolymer of different concentrations of ART with different concentrations of MNPs-Fe₃O₄.

Notes: *P < 0.05, compared with ART alone.

Abbreviations: MNPs-Fe₃O₄, magnetic nanoparticles of Fe₃O₄; ART, artesunate.

Figure 5 Expressions of bcl-2, bax, bcl-rambo, survivin, and caspase-3 protein in K562 cells.

Notes: Lane 1) K562 control; Lane 2) 1 μM MNP_s-Fe₃O₄; Lane 3) 100 μM ART; Lane 4) the copolymer of 100 μM ART with 1 μM MNPs-Fe₃O₄.

Abbreviations: MNPs-Fe₃O₄, magnetic nanoparticles of Fe₃O₄; ART, artesunate.