Figures & data
Figure 1 (A) Schematic of SPDS. (B) The structure profile of pressure measuring device. (C) The images of developed pressure measuring device.
Abbreviations: SPDS, Smartphone-Assisted Pressure-Measuring-Based Diagnosis System; PtNPs, platinum nanoparticles; AMI, acute myocardial infarction.
Figure 2 (A) The variation of Z-potential of PtNPs before and after labeling with different antibodies. (B) The variation of Z-average diameter of PtNPs before and after labeling with different antibodies. (C) Evaluation of the effect of antibody labeling on PtNPs catalytic efficiency.
Abbreviations: cTnI, cardiac troponin I; CK-MB, MB isoenzyme of creatine kinase; Myo, myoglobin; PtNPs, platinum nanoparticles.
Figure 3 Matrix effect evaluation for (A) cTnI, (B) CK-MB, and (C) Myo, standard curve for (D) cTnI, (E) CK-MB, and (F) Myo detection, and specificity evaluation result for (G) cTnI, (H) CK-MB, and (I) Myo.
Abbreviations: cTnI, cardiac troponin I; CK-MB, MB isoenzyme of creatine kinase; Myo, myoglobin; Thr, thrombin; Hb, hemoglobin; HSA, human serum albumin; IgG, immunoglobulin G; CRP, C-reactive protein.
Figure 4 Measuring result comparison between SPDS and CLIA: (A) correlation analysis for cTnI; (B) Bland–Altman analysis for cTnI detection; (C) correlation analysis for CK-MB; (D) Bland–Altman analysis for CK-MB detection; (E) correlation analysis for Myo; (F) Bland–Altman analysis for Myo detection.
Abbreviations: SPDS, Smartphone-Assisted Pressure-Measuring-Based Diagnosis System; CLIA, chemiluminescence immunoassay; cTnI, cardiac troponin I; CK-MB, MB isoenzyme of creatine kinase; Myo, myoglobin.
Figure S1 Optimization result of H2O2 concentration.
Figure S2 The nanoparticle zeta-average diameter profile of PtNPs before labeling (A) and after labeling for cTnI (B), CK-MB (C), and Myo (D).
Abbreviations: PtNPs, platinum nanoparticles; cTnI, cardiac troponin I; CK-MB, MB isoenzyme of creatine kinase; Myo, myoglobin.
Figure S3 Linearly fitting results for cTnI (A), CK-MB (B), and Myo (C) under low concentrations.
Abbreviations: cTnI, cardiac troponin I; CK-MB, MB isoenzyme of creatine kinase; Myo, myoglobin.
