238
Views
16
CrossRef citations to date
0
Altmetric
Original Research

A new biosensor detection system to overcome the Debye screening effect: dialysis-silicon nanowire field effect transistor

, , , , , , , , , & show all
Pages 2985-2993 | Published online: 30 Apr 2019

Figures & data

Figure 1 The relationship between debye length and ionic strength.

Figure 1 The relationship between debye length and ionic strength.

Figure 2 (A) The detection principle of SiNW-FET. (B) The principle of the Debye screening effect. (C–E) A schematic diagram of a miniature blood dialyzer.

Abbreviation: SiNW-FET, silicon nanowire field effect transistor.

Figure 2 (A) The detection principle of SiNW-FET. (B) The principle of the Debye screening effect. (C–E) A schematic diagram of a miniature blood dialyzer.Abbreviation: SiNW-FET, silicon nanowire field effect transistor.

Figure 3 The fabrication process for silicon nanowire devices.

Abbreviation: SiNW, silicon nanowire.

Figure 3 The fabrication process for silicon nanowire devices.Abbreviation: SiNW, silicon nanowire.

Figure 4 The process of functional modification of silicon nanowires.

Figure 4 The process of functional modification of silicon nanowires.

Figure 5 The image of the miniature blood dialyzer.

Figure 5 The image of the miniature blood dialyzer.

Figure 6 The structure and properties of silicon nanowire devices. (A) An SEM image of SiNW. (B) A schematic of the distribution of the electrodes in a silicon nanowire device. (C) The transfer curve image. (D) The output curve image.

Abbreviation: SiNW, silicon nanowire.

Figure 6 The structure and properties of silicon nanowire devices. (A) An SEM image of SiNW. (B) A schematic of the distribution of the electrodes in a silicon nanowire device. (C) The transfer curve image. (D) The output curve image.Abbreviation: SiNW, silicon nanowire.

Figure 7 The results of functional silicon nanowire modification. (A) The AFM image of functioned SiNW. (B) The results after modification of the fluorescent protein. Abbreviation: SiNW, silicon nanowire.

Figure 7 The results of functional silicon nanowire modification. (A) The AFM image of functioned SiNW. (B) The results after modification of the fluorescent protein. Abbreviation: SiNW, silicon nanowire.

Table 1 Compositional variation in the serum before and after dialysis

Figure 8 The detection results on Dialysis–SiNW-FET. (A) The standard solution detection results of anti-CEA SiNW-FET. (B) The standard solution detection results of anti-AFP SiNW-FET. (C) The standard solution detection results of no antibody SiNW-FET and anti-BSA SiNW-FET. (D) The serum detection results of anti-CEA SiNW-FET. (E) The serum detection results of anti-AFP SiNW-FET. (F) The serum detection results of anti-BSA SiNW-FET.

Abbreviation: SiNW-FET, silicon nanowire field effect transistor.

Figure 8 The detection results on Dialysis–SiNW-FET. (A) The standard solution detection results of anti-CEA SiNW-FET. (B) The standard solution detection results of anti-AFP SiNW-FET. (C) The standard solution detection results of no antibody SiNW-FET and anti-BSA SiNW-FET. (D) The serum detection results of anti-CEA SiNW-FET. (E) The serum detection results of anti-AFP SiNW-FET. (F) The serum detection results of anti-BSA SiNW-FET.Abbreviation: SiNW-FET, silicon nanowire field effect transistor.

Figure 9 The human serum detection results of different tumor markers. (A) The human serum detection results with different CEA concentrations. (B) The human serum detection results with different AFP concentrations.

Figure 9 The human serum detection results of different tumor markers. (A) The human serum detection results with different CEA concentrations. (B) The human serum detection results with different AFP concentrations.