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Original Research

Investigation of gold nanoparticle effects in brachytherapy by an electron emitter ophthalmic plaque

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Pages 4157-4165 | Published online: 06 Jun 2019

Figures & data

Figure 1 (A) The energy spectrum of 106Ru/106Rh1717 and (B) CCB concave model of 106Ru eye applicator.

Figure 1 (A) The energy spectrum of 106Ru/106Rh1717 and (B) CCB concave model of 106Ru eye applicator.

Figure 2 Eye geometry defined in the MCNPX simulation code and CCB applicator sewn on the sclera.

Figure 2 Eye geometry defined in the MCNPX simulation code and CCB applicator sewn on the sclera.

Figure 3 Experimental phantom (left) and CCB plaque along with EBT2 film on the phantom in the experimental dosimetry (right).

Figure 3 Experimental phantom (left) and CCB plaque along with EBT2 film on the phantom in the experimental dosimetry (right).

Figure 4 RDD of simulation and experiment, normalized at 3 mm distance from the plaque.

Figure 4 RDD of simulation and experiment, normalized at 3 mm distance from the plaque.

Figure 5 Dose rate comparison between manufacturer and simulation data.

Figure 5 Dose rate comparison between manufacturer and simulation data.

Figure 6 Simulation results for Plexiglas and water phantom.

Figure 6 Simulation results for Plexiglas and water phantom.

Figure 7 PDD comparison with and without different GNP’s concentration.

Figure 7 PDD comparison with and without different GNP’s concentration.

Figure 8 Dose enhancement factor for different concentration of GNPs.

Figure 8 Dose enhancement factor for different concentration of GNPs.

Figure 9 Energy deposition profile in three distance of plaque: (up-left) 1.3 mm and in the tumor base, (up-right) 3 mm and in the tumor middle, (down) 5 mm and in the tumor apex.

Figure 9 Energy deposition profile in three distance of plaque: (up-left) 1.3 mm and in the tumor base, (up-right) 3 mm and in the tumor middle, (down) 5 mm and in the tumor apex.

Figure 10 Energy deposition in tumor cell (left) and sclera (right) at different concentration of GNPs.

Figure 10 Energy deposition in tumor cell (left) and sclera (right) at different concentration of GNPs.

Figure 11 Effect of 5.7 mgAu/grTissue in the tissues outside the tumor for 20 mgAu/grTumor inside the tumor. DEFs were measured at the central axis of plaque.

Figure 11 Effect of 5.7 mgAu/grTissue in the tissues outside the tumor for 20 mgAu/grTumor inside the tumor. DEFs were measured at the central axis of plaque.