Figures & data
Figure 1 The ternary phase diagram of the colchicine nanoemulsion system containing Tween80, ethanol, distilled water and isopropyl myristate (IPM), eugenol as surfactant, water, and oil system. The shaded areas in the phase diagram represent clear and transparent nanoemulsions.
Figure 2 Transmission electron microphotograph of colchicine nanoemulsion.
Figure 3 Concentration-dependent effects of eugenol on absorptive (mucosal to serosal, M to S) transport of colchicine in the rat jejunum. The concentrations of eugenol were 0.5%–2% w/w. Results are expressed as the mean ± SD of at least 3 experiments.
Figure 4 Time course of absorptive (mucosal to serosal, M to S) and secretory (S to M) transport of colchicine across the rat jejunal membrane in the presence of 2% eugenol (w/w), nanoemulsion (NE) and eugenol–nanoemulsion (eugenol–NE). Results are expressed as the mean±SD of at least three experiments.
Table 1 Effects of eugenol and nanoemulsion (NE) on the permeability of colchicine across the intestinal jejunal membranes
Table 2 Pharmacokinetic parameters of colchicine after oral administration in rats in the presence or absence of eugenol–nanoemulsion (eugenol–NE)
Figure 5 Plasma concentration–time profile of colchicine after oral administration with nanoemulsion (NE) or with eugenol nanoemulsion (eugenol–NE). Results are expressed as the mean ± SD of at least 3 experiments.
