Figures & data
Figure 1 Chemical structure of sildenafil citrate.
Table 1 Composition of sildenafil citrate (SC)-loaded solid lipid nanoparticle formulations (% w/v)Table Footnotea
Table 2 Composition of sildenafil citrate (SC)-loaded nanostructured lipid carrier formulations (% w/v)Table Footnotea
Table 3 Characterization of sildenafil citrate (SC)-loaded solid lipid nanoparticles
Table 4 Characterization of sildenafil citrate (SC)-loaded nanostructured lipid carriers
Table 5 Peak onset, melting point, and enthalpy data of differential scanning calorimetry analysis
Figure 2 Differential scanning calorimetry thermograms of cetyl palmitate (CP); CP:Maisine™ 35-1 physical mixture (CP:M PH MIX) (0.7:0.3); CP:M:Cremophor® RH 40 physical mixture (CP:M:CR PH MIX) (0.7:0.3:1.3); nanostructured lipid carriers (NLCs), solid lipid nanoparticles (SLNs), and sildenafil citrate (SC).
Figure 3 In vitro release profiles of sildenafil citrate from nanostructured lipid carriers (NLCs), and solid lipid nanoparticles (SLNs) compared with drug suspension in carbonate buffer (pH 10.3) (citrate buffer, pH 5).
Figure 4 Transdermal permeation of sildenafil citrate (SC)-loaded nanoparticles across human skin versus drug suspensions in water and carbonate buffer (pH 10.3) (citrate buffer, pH 5).
Abbreviations: NLC, nanostructured lipid carrier; SLN, solid lipid nanoparticle.
Table 6 Stability study of sildenafil citrate-loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs): selected formulations (X6, N6)