Figures & data
Figure 1 Pharmacological activities of Curcumin.
![Figure 1 Pharmacological activities of Curcumin.](/cms/asset/a9d85060-5177-47ac-bac8-73411404b9f6/dijn_a_276201_f0001_c.jpg)
Table 1 The Influential Effect and Preparation Method of CUR-Loaded Physicochemical Targeting Preparations
Table 2 The Trigger/Targeting Carries and Preparation Method of CUR-Loaded Physicochemical Targeting Preparations
Figure 4 Schematic representation of liposomal coating with Eudragit@ S100 by the pH jump method.
![Figure 4 Schematic representation of liposomal coating with Eudragit@ S100 by the pH jump method.](/cms/asset/562b12aa-7362-4c6b-94ce-1f14151ff01e/dijn_a_276201_f0004_c.jpg)
Figure 5 Representative ex vivo images of tumor and main organs (heart, liver, spleen, lung, and kidney) after administration of DOX and PEG-Dox-CUR NPs.
Reprinted from Zhang Y, Yang C, Wang W, et al. Co-delivery of doxorubicin and curcumin by pH-sensitive prodrug nanoparticle for combinationtherapy of cancer. Sci Rep. 2016;6(1):21225. This work is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). Citation55
![Figure 5 Representative ex vivo images of tumor and main organs (heart, liver, spleen, lung, and kidney) after administration of DOX and PEG-Dox-CUR NPs.Reprinted from Zhang Y, Yang C, Wang W, et al. Co-delivery of doxorubicin and curcumin by pH-sensitive prodrug nanoparticle for combinationtherapy of cancer. Sci Rep. 2016;6(1):21225. This work is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). Citation55](/cms/asset/98d0af52-2781-4ecc-834b-b2a12ef16013/dijn_a_276201_f0005_c.jpg)
Figure 6 Evaluation of experimental colitis in the colon of mice in (A) control group (severe lesions and inflammation), (B) CUR-treated group (moderate lesions), and (C) CUR microsphere-treated group (mild lesions).
Reprinted with permission from Sareen R, Jain N, Rajkumari A, et al. pH triggered delivery of curcumin from Eudragit-coated chitosan microspheres for inflammatory bowel disease: characterization and pharmacodynamic evaluation. Drug Delivery. 2016;23(1):55–62. Copyright (2016) Taylor & Francis Ltd (http://www.tandfonline.com).Citation74
![Figure 6 Evaluation of experimental colitis in the colon of mice in (A) control group (severe lesions and inflammation), (B) CUR-treated group (moderate lesions), and (C) CUR microsphere-treated group (mild lesions).Reprinted with permission from Sareen R, Jain N, Rajkumari A, et al. pH triggered delivery of curcumin from Eudragit-coated chitosan microspheres for inflammatory bowel disease: characterization and pharmacodynamic evaluation. Drug Delivery. 2016;23(1):55–62. Copyright (2016) Taylor & Francis Ltd (http://www.tandfonline.com).Citation74](/cms/asset/b9aae11f-7c93-4008-a6e3-83d5e106cd78/dijn_a_276201_f0006_c.jpg)
Figure 7 Representative confocal images of (A) nano-Fe3O4-coated with CUR on SKOV-3, and (B) nano-Fe3O4-coated with CUR on SKOV-3 enhanced by magnetic field (Blue cells nuclei are labeled with DAPI, green nano-Fe3O4 are labeled with FITC (DXS-FITC), and red actin filaments are labeled with phalloidin-TRITC).
![Figure 7 Representative confocal images of (A) nano-Fe3O4-coated with CUR on SKOV-3, and (B) nano-Fe3O4-coated with CUR on SKOV-3 enhanced by magnetic field (Blue cells nuclei are labeled with DAPI, green nano-Fe3O4 are labeled with FITC (DXS-FITC), and red actin filaments are labeled with phalloidin-TRITC).](/cms/asset/9d67e60a-9412-4a85-a045-568b38e2023e/dijn_a_276201_f0007_c.jpg)