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International Journal of Nanomedicine Volume 7, 2012 - Issue
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Original Research

Degradable biocomposite of nano calcium-deficient hydroxyapatite-multi(amino acid) copolymer

Hong Li1 School of Physical Science and Technology, Sichuan University, Chengdu People’s Republic of China
,
Min Gong1 School of Physical Science and Technology, Sichuan University, Chengdu People’s Republic of China
,
Aiping Yang1 School of Physical Science and Technology, Sichuan University, Chengdu People’s Republic of ChinaCorrespondence[email protected]
,
Jian Ma2 Hospital of Stomatology, Tongji University, Shanghai, People’s Republic of China
,
Xiangde Li3 Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, People’s Republic of China
&
Yonggang Yan1 School of Physical Science and Technology, Sichuan University, Chengdu People’s Republic of China
Pages 1287-1295 | Published online: 08 Mar 2012

Figures & data

Figure 1 Transmission electron microscopic image of nano calcium-deficient hydroxyapatite.

Figure 1 Transmission electron microscopic image of nano calcium-deficient hydroxyapatite.

Figure 2 Infrared spectra of multi(amino acid) copolymer (A), nano calcium-deficient hydroxyapatite (B), and 30 wt% nano calcium-deficient hydroxyapatite-multi(amino acid) polymer composite (C).

Figure 2 Infrared spectra of multi(amino acid) copolymer (A), nano calcium-deficient hydroxyapatite (B), and 30 wt% nano calcium-deficient hydroxyapatite-multi(amino acid) polymer composite (C).

Figure 3 X-ray diffraction patterns of multi(amino acid) copolymer (A), nano calcium-deficient hydroxyapatite (B), and 30 wt% nano calcium-deficient hydroxyapatite-multi(amino acid) copolymer composite (C).

Figure 3 X-ray diffraction patterns of multi(amino acid) copolymer (A), nano calcium-deficient hydroxyapatite (B), and 30 wt% nano calcium-deficient hydroxyapatite-multi(amino acid) copolymer composite (C).

Figure 4 Cross-sectional morphology of 30 wt% nano calcium-deficient hydroxyapatite-multi(amino acid) copolymer composite.

Figure 4 Cross-sectional morphology of 30 wt% nano calcium-deficient hydroxyapatite-multi(amino acid) copolymer composite.

Figure 5 Effects of nano calcium-deficient hydroxyapatite (n-CDHA) contents on the compressive strength of nano calcium-deficient hydroxyapatite-multi(amino acid) copolymer composite.

Note: *P < 0.05.

Figure 5 Effects of nano calcium-deficient hydroxyapatite (n-CDHA) contents on the compressive strength of nano calcium-deficient hydroxyapatite-multi(amino acid) copolymer composite.Note: *P < 0.05.

Figure 6 Weight loss of the nano calcium-deficient hydroxyapatite-multi(amino acid) copolymer (CDHA/MAC) composite after soaking in phosphate-buffered solution with time.

Abbreviation: MAC, multi(amino acid) copolymer.

Figure 6 Weight loss of the nano calcium-deficient hydroxyapatite-multi(amino acid) copolymer (CDHA/MAC) composite after soaking in phosphate-buffered solution with time.Abbreviation: MAC, multi(amino acid) copolymer.

Figure 7 pH change of the phosphate-buffered solution after nano calcium-deficient hydroxyapatite-multi(amino acid) copolymer (CDHA/MAC) composite soaking with time.

Abbreviation: MAC, multi(amino acid) copolymer.

Figure 7 pH change of the phosphate-buffered solution after nano calcium-deficient hydroxyapatite-multi(amino acid) copolymer (CDHA/MAC) composite soaking with time.Abbreviation: MAC, multi(amino acid) copolymer.

Figure 8 Viability of MG-63 cells on 30 wt% nano calcium-deficient hydroxyapatite-multi(amino acid) copolymer (30CDHA/MAC) composite by MTT assay at 1, 3, 5 and 7 days (MAC and tissue culture plate as controls).

Note: *P < 0.05.

Abbreviations: MAC, multi(amino acid) copolymer; TCP, tissue culture plate.

Figure 8 Viability of MG-63 cells on 30 wt% nano calcium-deficient hydroxyapatite-multi(amino acid) copolymer (30CDHA/MAC) composite by MTT assay at 1, 3, 5 and 7 days (MAC and tissue culture plate as controls).Note: *P < 0.05.Abbreviations: MAC, multi(amino acid) copolymer; TCP, tissue culture plate.

Figure 9 ALP activity of MG-63 cells cultured on 30 wt% nano calcium-deficient hydroxyapatite-multi(amino acid) copolymer (30CDHA/MAC) composite, multi(amino acid) copolymer (MAC), and tissue culture plate (TCP) as controls.

Note: *P < 0.05.

Abbreviation: ALP, alkaline phosphatase.

Figure 9 ALP activity of MG-63 cells cultured on 30 wt% nano calcium-deficient hydroxyapatite-multi(amino acid) copolymer (30CDHA/MAC) composite, multi(amino acid) copolymer (MAC), and tissue culture plate (TCP) as controls.Note: *P < 0.05.Abbreviation: ALP, alkaline phosphatase.

Figure 10 Scanning electron microscopic images of MG-63 cells cultured on multi(amino acid) copolymer (A) and 30 wt% nano calcium-deficient hydroxyapatite-multi(amino acid) copolymer composite (B) for 3 days.

Figure 10 Scanning electron microscopic images of MG-63 cells cultured on multi(amino acid) copolymer (A) and 30 wt% nano calcium-deficient hydroxyapatite-multi(amino acid) copolymer composite (B) for 3 days.

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