Figures & data
Figure 1 Electrospinning apparatus.
Figure 2 Scanning electron microscopic images of electrospun, sandwich-structured nanofibers. (A) Top PLGA/collagen layer, (B) PLGA/vancomycin/gentamycin/lidocaine at the core, and (C) bottom PLGA/collagen layer.
Abbreviation: PLGA, poly(D, L)-lactide-co-glycolide.
Figure 3 Stress-strain curve of the nanofibrous membrane.
Figure 4 In vitro release behavior of vancomycin, gentamicin, and lidocaine from nanofibrous membranes.
Figure 5 In vivo release of vancomycin and its bioactivity.
Figure 6 In vivo release of gentamicin and its bioactivity.
Figure 7 In vivo release of lidocaine from nanofibrous membranes.
Figure 8 Appearance of wound healing at weeks 1, 2, and 3 after grafting. (A) PLGA/collagen group and (B) PLGA/collagen with vancomycin, gentamicin, and lidocaine group (rectangular wounds 2 cm × 2 cm were prepared on each rat’s back, as shown in A1 and B1).
Abbreviation: PLGA, poly(D, L)-lactide-co-glycolide.
Figure 9 Histological images of (A) PLGA/collagen group and (B) PLGA/collagen with vancomycin, gentamicin, and lidocaine group at weeks 1, 2, and 3. (No necrosis was observed in B3).
Abbreviation: PLGA, poly(D, L)-lactide-co-glycolide.
