Figures & data
Figure 1 Scheme of drug-releasing implants for local delivery of therapeutics in the brain based on Ti wire with titania nanotube (TNT) arrays on the surface generated by electrochemical anodization. Dopamine (brain neurotransmitter) and doxorubicin (anticancer drug) were used as model drugs.
Abbreviations: Ti, titanium; TiO2, titanium dioxide; TNT, titania nanotube.
![Figure 1 Scheme of drug-releasing implants for local delivery of therapeutics in the brain based on Ti wire with titania nanotube (TNT) arrays on the surface generated by electrochemical anodization. Dopamine (brain neurotransmitter) and doxorubicin (anticancer drug) were used as model drugs.Abbreviations: Ti, titanium; TiO2, titanium dioxide; TNT, titania nanotube.](/cms/asset/a8c87520-06bc-40cd-8bff-0691c3e56313/dijn_a_29917_f0001_c.jpg)
Figure 2 SEM images of titania nanotube (TNT) arrays generated on Ti wires by electrochemical anodization. (A) TNT/Ti wire implant, (B and C) low and high resolution image showing fractures of TNT film, (D–F) cross-sectional image and the top TNT surface showing typical nanotube structures.
Abbreviations: SEM, scanning electron microscope; TNT, titania nanotube; Ti, titanium.
![Figure 2 SEM images of titania nanotube (TNT) arrays generated on Ti wires by electrochemical anodization. (A) TNT/Ti wire implant, (B and C) low and high resolution image showing fractures of TNT film, (D–F) cross-sectional image and the top TNT surface showing typical nanotube structures.Abbreviations: SEM, scanning electron microscope; TNT, titania nanotube; Ti, titanium.](/cms/asset/6cbcfbfc-0c4f-4fd2-8793-bbb8a650d557/dijn_a_29917_f0002_c.jpg)
Figure 3 Thermogravimetric (TGA) graphs showing drug loading of (A) dopamine and (B) doxorubicin into TNT/Ti wire.
Abbreviations: TGA, thermogravimetric analysis; TNT, titania nanotube; Ti, titanium.
![Figure 3 Thermogravimetric (TGA) graphs showing drug loading of (A) dopamine and (B) doxorubicin into TNT/Ti wire.Abbreviations: TGA, thermogravimetric analysis; TNT, titania nanotube; Ti, titanium.](/cms/asset/0a51ca46-b8be-4217-ac79-dd42156fe077/dijn_a_29917_f0003_c.jpg)
Table 1 Drug release characteristics of two drugs (dopamine and doxorubicin) from TNT/Ti wire showing their drug loading and release characteristics (% and mass) during burst and 8-days release period