Figures & data
Figure 1 Scheme for the association between biomarkers (CRP) and magnetic nanoparticles coated with antibodies (anti-CRP). The magnetic nanoparticles become larger or clustered due to binding with biomarkers (CRP), as circled with the dashed line.
Abbreviation: CRP, C-reactive protein.
Figure 2 Immunomagnetic reduction assay of CRP. (A) Real-time signal of χac magnetic reagent after being mixed with 4.99 mg/dL CRP serum. (B) IMR signals for independent triple tests of 4.99 mg/dL CRP serum.
Abbreviations: CRP, C-reactive protein; IMR, immunomagnetic reduction.
Figure 3 Immunoturbidimetric intensity (dashed line) and IMR signal (solid line) as functions of CRP concentration in pure CRP solution (dot symbols) and diluted human serum (rhombus symbols).
Abbreviations: CRP, C-reactive protein; IMR, immunomagnetic reduction.
Figure 4 Correlation between CRP concentrations in human serum measured via IMR (denoted as CRP+) and immunoturbidimetry (denoted as CRP*).
Abbreviations: CRP, C-reactive protein; IMR, immunomagnetic reduction.
Table 1 Numbers in positive group and negative group detected via immunoturbidimetry and IMR
Figure 5 Detected concentrations of CRP in serum with CRP only and other biomarkers (A) unconjugated bilirubin (UC bilirubin), (B) conjugated bilirubin (C bilirubin), (C) hemoglobin, and (D) intrafat via IMR.
Abbreviations: CRP, C-reactive protein; IMR, immunomagnetic reduction.
