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Original Research

pH and temperature dual-sensitive liposome gel based on novel cleavable mPEG-Hz-CHEMS polymeric vaginal delivery system

, , , , , , , , , & show all
Pages 2621-2630 | Published online: 28 May 2012

Figures & data

Figure 1 A schematic diagram of the strategy of mPEG-Hz-CHEMS cleavable dual-sensitive liposome gels.

Abbreviation: mPEG-Hz-CHEMS, methoxy polyethylene glycol 2000-hydrazonecholesteryl hemisuccinate.

Figure 1 A schematic diagram of the strategy of mPEG-Hz-CHEMS cleavable dual-sensitive liposome gels.Abbreviation: mPEG-Hz-CHEMS, methoxy polyethylene glycol 2000-hydrazonecholesteryl hemisuccinate.

Table 1 The physicochemical parameters of AC-loading pH-sensitive liposomes and plain AC liposomes

Figure 2 The structure and 1H-NMR spectra of mPEG-Hz-CHEMS in CDCl3.

Figure 2 The structure and 1H-NMR spectra of mPEG-Hz-CHEMS in CDCl3.

Figure 3 FT-IR spectra of blank gels (A), AC liposomes (B), AC dual-sensitive gels (C).

Abbreviation: AC, arctigenin.

Figure 3 FT-IR spectra of blank gels (A), AC liposomes (B), AC dual-sensitive gels (C).Abbreviation: AC, arctigenin.
Figure 3 FT-IR spectra of blank gels (A), AC liposomes (B), AC dual-sensitive gels (C).Abbreviation: AC, arctigenin.

Figure 4 DSC curves of AC (A), AC liposomes (B), AC dual-sensitive gels (C).

Abbreviation: AC, arctigenin.

Figure 4 DSC curves of AC (A), AC liposomes (B), AC dual-sensitive gels (C).Abbreviation: AC, arctigenin.

Figure 5 The sol-gel transition observation of AC dual-sensitive gels over the gelation temperature (A), gelation (B), and under the gelation temperature (C).

Abbreviation: AC, arctigenin.

Figure 5 The sol-gel transition observation of AC dual-sensitive gels over the gelation temperature (A), gelation (B), and under the gelation temperature (C).Abbreviation: AC, arctigenin.

Figure 6 pH-sensitive profiles of AC dual-sensitive gels (n = 3).

Abbreviation: AC, arctigenin.

Figure 6 pH-sensitive profiles of AC dual-sensitive gels (n = 3).Abbreviation: AC, arctigenin.

Figure 7 In vitro release of AC dual-sensitive gels at pH 5.0, 7.4 and 9.0.

Abbreviation: AC, arctigenin.

Figure 7 In vitro release of AC dual-sensitive gels at pH 5.0, 7.4 and 9.0.Abbreviation: AC, arctigenin.

Figure 8 Cytotoxicity of AC dual-sensitive gels.

Notes: Data represent the mean ± SD (n = 6). *P < 0.05, compared with the free AC.

Abbreviation: AC, arctigenin.

Figure 8 Cytotoxicity of AC dual-sensitive gels.Notes: Data represent the mean ± SD (n = 6). *P < 0.05, compared with the free AC.Abbreviation: AC, arctigenin.