https://orcid.org/0000-0002-6486-9835
Figures & data
Figure 1 General structure and properties of lysosomes. Lysosome lipid bilayer with peripheral and integral membrane proteins with different functions.
Figure 2 The lysosome as an intracellular signaling core. Different types of cellular processes being controlled by signaling pathways and commenced from the surface of lysosomes.
Figure 3 The inhibition of PPT1 by DQ661 and the regulation of multiple lysosome-facilitated signaling processes. The left half of the lysosome median line indicates the basal (control) conditions in absence of DQ661. The right side of the lysosome median line shows the effect of DQ661 binding to PPT1 directly within the lysosomal lumen, resulting in decreased macropinocytosis, autophagic flux, proliferation, and decreased tumor growth and enhanced apoptosis.
Table 1 Different Types of LMP Inducers and Their Mechanisms of Action
Table 2 Examples of Different Compounds Which Act as Modulators of Autophagy Used as Cancer Prevention and Therapy and the Examples of Different Cancer Where Used
Table 3 Examples of Different Drugs and Other Compounds Which Modulate the Iron Metabolism Mediated Ferroptosis with Different Types of Mechanisms
Figure 4 Chemical structure of some important lysosomotropic compounds used to induce LMP.
Figure 5 The role of mixed charged NPs within normal and cancer cells. Normal cells clear these NPs through proper exocytosis and are least damaged. In cancer cells these NPs form superacrystals and lead to lysosome breakdown resulting in cell death.
Table 4 Different Lysosome-Targeted Nanoformulations Used for Therapy and Imaging Purpose Based on Autophagy and Non-Endocytic Uptake in Different Cancer Cell Types