Formation of methotrexate-PLLA-PEG-PLLA composite microspheres by microencapsulation through a process of suspension-enhanced dispersion by supercritical CO₂

Ai-Zheng Chen1 College of Chemical Engineering, Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China;2 Institute of Pharmaceutical Engineering, Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China

Guang-Ya Wang1 College of Chemical Engineering, Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China

Shi-Bin Wang1 College of Chemical Engineering, Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China;2 Institute of Pharmaceutical Engineering, Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, ChinaCorrespondence[email protected] [email protected]

Li Li1 College of Chemical Engineering, Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China

Yuan-Gang Liu1 College of Chemical Engineering, Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China;2 Institute of Pharmaceutical Engineering, Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China

Chen Zhao1 College of Chemical Engineering, Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China

Formation of methotrexate-PLLA-PEG-PLLA composite microspheres by microencapsulation through a process of suspension-enhanced dispersion by supercritical CO₂

Table 1 Particle size and particle size distribution of (A) methotrexate nanoparticles prepared by SEDS, and MTX-PLLA-PEG-PLLA microspheres from (B) microencapsulation process and (C) coprecipitation process with a drug dose of 10%

Table 2 Correlation coefficient and standard deviation obtained from the first-order release kinetics fitting of drug release profiles of MTX-PLLA-PEG-PLLA microspheres prepared by the coprecipitation process with different drug doses

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Formation of methotrexate-PLLA-PEG-PLLA composite microspheres by microencapsulation through a process of suspension-enhanced dispersion by supercritical CO2

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Table 1 Particle size and particle size distribution of (A) methotrexate nanoparticles prepared by SEDS, and MTX-PLLA-PEG-PLLA microspheres from (B) microencapsulation process and (C) coprecipitation process with a drug dose of 10%

Table 2 Correlation coefficient and standard deviation obtained from the first-order release kinetics fitting of drug release profiles of MTX-PLLA-PEG-PLLA microspheres prepared by the coprecipitation process with different drug doses

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Formation of methotrexate-PLLA-PEG-PLLA composite microspheres by microencapsulation through a process of suspension-enhanced dispersion by supercritical CO₂