Figures & data
Figure 1 Schematic illustration of synthesis of Cy5.5-conjugated zinc oxide nanoparticles.
Figure 2 Fourier transform infrared spectra of nonmodified zinc oxide nanoparticles (dotted blue line) and amino-zinc oxide nanoparticles (solid red line).
Figure 3 Optical images of distilled water (left) and Cy5.5-conjugated zinc oxide nanoparticles (right).
Figure 4 In vitro stability study for Cy5.5 conjugation on (A) nanoscaled and (B) submicron-scaled zinc oxide nanoparticles in HCl solution (pH 1.2).
Figure 5 In vivo translocation of (A) Cy5.5-NHS and (B) Cy5.5-conjugated zinc oxide nanoparticles into the blood after oral administration.
Figure 6 In vivo optical images of rats orally administered with (A) Cy5.5-NHS, (B) Cy5.5-conjugated nanoscaled zinc oxide nanoparticles, and (C) Cy5.5-conjugated submicron-scaled zinc oxide nanoparticles at hours 1, 2, 3, 5, and 7 after administration.
Figure 7 Ex vivo optical images of major rat organs after oral administration with (A) Cy5.5-NHS, (B) Cy5.5-conjugated nanoscaled zinc oxide nanoparticles, and (C) Cy5.5-conjugated submicron-scaled zinc oxide nanoparticles at 7 hours after administration.
Figure 8 Quantification of ex vivo images after oral administration of (A) Cy5.5-NHS, (B) Cy5.5-conjugated nanoscaled zinc oxide nanoparticles, and (C) Cy5.5-conjugated submicron-scaled zinc oxide nanoparticles at 7 hours after administration.
