Figures & data
Table 1 Advantages and disadvantages of chitosan microspheres prepared by various methods
Table 2 Chitosan-based carrier systems with functional properties for the delivery of (model) vaccines through oral and nasal routes
Figure 2 Scanning electron microscope photographs of CMs, BBD-loaded CMs, MCMs, and BBD-loaded MCMs (5000×).
Notes: Bar represents 5 μm. Reprinted from Biomaterials, 29(12). Jiang HL, Kang ML, Quan JS, et al. The potential of mannosylated chitosan microspheres to target macrophage mannose receptors in an adjuvant-delivery system for intranasal immunization, 1931–1939. Copyright 2008 with permission from Elsevier.Citation91
Abbreviations: BBD, Bordetella bronchiseptica dermonecrotoxin; CM, chitosan microsphere; MCM, mannosylated chitosan microsphere.
![Figure 2 Scanning electron microscope photographs of CMs, BBD-loaded CMs, MCMs, and BBD-loaded MCMs (5000×).Notes: Bar represents 5 μm. Reprinted from Biomaterials, 29(12). Jiang HL, Kang ML, Quan JS, et al. The potential of mannosylated chitosan microspheres to target macrophage mannose receptors in an adjuvant-delivery system for intranasal immunization, 1931–1939. Copyright 2008 with permission from Elsevier.Citation91Abbreviations: BBD, Bordetella bronchiseptica dermonecrotoxin; CM, chitosan microsphere; MCM, mannosylated chitosan microsphere.](/cms/asset/5bede4af-6d68-4b80-8058-071f2d0249d4/dijn_a_38330_f0002_b.jpg)
Figure 3 Representative structure of thiolated chitosan: (A) general structure of thiolated chitosan modified by an –SH group (X: linker) and (B) chitosan-N-acetyl-cysteine (modification of chitosan at the D-glucosamine unit by N-acetyl-cysteine).
![Figure 3 Representative structure of thiolated chitosan: (A) general structure of thiolated chitosan modified by an –SH group (X: linker) and (B) chitosan-N-acetyl-cysteine (modification of chitosan at the D-glucosamine unit by N-acetyl-cysteine).](/cms/asset/d61dfaf5-f00f-4c09-93e5-721b8876405b/dijn_a_38330_f0003_b.jpg)
Figure 4 Schematic representation of functional interaction between TCMs and mucin in mucosal vaccine delivery.
Abbreviation: TCM, thiolated chitosan microsphere.
![Figure 4 Schematic representation of functional interaction between TCMs and mucin in mucosal vaccine delivery.Abbreviation: TCM, thiolated chitosan microsphere.](/cms/asset/cb08c850-ee8e-45af-a449-7121f1f6d689/dijn_a_38330_f0004_c.jpg)