Novel Carbon Dots Derived from Moutan Cortex Significantly Improve the Solubility and Bioavailability of Mangiferin

Figures & data

Figure 1 Preparation scheme of Moutan Cortex-Carbon dots (MC-CDs).

Figure 2 Characteristics of MC-CDs. (A) Transmission Electron Microscope (TEM) of MC-CDs. (B) TEM size distribution of MC-CDs. (C) High Resolution Transmission Electron Microscope of MC-CDs. (D) Lattice spacing of MC-CDs in HRTEM. (E) Ultraviolet-visible spectroscopy (UV-Vis) of MC-CDs. (F) Fourier-transform infrared spectrometer (FTIR) of MC-CDs. (G) XRD pattern of MC-CDs. (H) Zeta potential values of MC-CDs.

Figure 3 The XPS of MC-CDs. (A) Full-survey XPS data. (B) The high-resolution C1s spectrum. (C) The high-resolution O1s spectrum. (D) The high-resolution N1s spectrum.

Figure 4 Luminescence properties of MC-CDs. (A) Emission and excitation wavelength fluorescence spectra. (B) Excitation spectra of the MC-CDs at emission wavelengths. (C) Emission spectra of the MC-CDs at different excitation wavelengths.

Figure 5 Cytotoxicity in HT-22 cells. All data are presented as the mean ± SD. ^#P < 0.05, **P < 0.01 between two groups.

Figure 6 Concentration profiles of MA in the aqueous MC-CDs solutions.

Table 1 Pharmacokinetic Parameters of MA in Rats After Oral Administration of MA Control and MA-MC-CDs

Parameter	Unit	MA	MA-MC-CDs
Cmax	ng/L	201.28 ± 31.38	323.98 ± 82.21
Tmax	h	4.00 ± 1.42	0.25 ± 0.76
t1/2	h	3.27 ± 2.18	7.22 ± 2.47
CL/F	L/h/kg	11,144.46 ± 4039.27	14,490.30 ± 3335.50
AUC0-t	ng/L·h	1523.45 ± 2638.01	1249.81 ± 186.09
MRT0-t	h	5.23 ± 0.60	5.96 ± 1.55

Figure 7 Effects of MC-CDs on the blood concentration-time curve of MA.

Data Sharing Statement

The data supporting the findings of this study are available upon request from the corresponding author.