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International Journal of Nanomedicine Volume 10, 2015 - Issue
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Original Research

Study of magnetic silk fibroin nanoparticles for massage-like transdermal drug delivery

Ai-Zheng Chen1 College of Chemical Engineering, Huaqiao University, Xiamen, People’s Republic of China;2 Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen, People’s Republic of China;3 Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen, People’s Republic of ChinaCorrespondence[email protected]
,
Lin-Qing Chen1 College of Chemical Engineering, Huaqiao University, Xiamen, People’s Republic of China
,
Shi-Bin Wang1 College of Chemical Engineering, Huaqiao University, Xiamen, People’s Republic of China;2 Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen, People’s Republic of China;3 Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen, People’s Republic of ChinaCorrespondence[email protected]
,
Ya-Qiong Wang1 College of Chemical Engineering, Huaqiao University, Xiamen, People’s Republic of China
&
Jun-Zhe Zha1 College of Chemical Engineering, Huaqiao University, Xiamen, People’s Republic of China
Pages 4639-4651 | Published online: 21 Jul 2015

Figures & data

Figure 1 Schematic diagram for preparation of the Fe3O4-SF nanoparticles.

Abbreviations: HPLC, high-performance liquid chromatography; SF, silk fibroin.

Figure 1 Schematic diagram for preparation of the Fe3O4-SF nanoparticles.Abbreviations: HPLC, high-performance liquid chromatography; SF, silk fibroin.

Figure 2 The experimental setup for permeation studies.

Notes: (A) Diffusion cell with stationary magnetic field; (B) diffusion cell with alternating magnetic field; and (C) diffusion cell with stationary/alternating magnetic fields.

Figure 2 The experimental setup for permeation studies.Notes: (A) Diffusion cell with stationary magnetic field; (B) diffusion cell with alternating magnetic field; and (C) diffusion cell with stationary/alternating magnetic fields.

Figure 3 SEM photographs of nanoparticles.

Notes: (A) Fe3O4-SF nanoparticles with an Fe3O4/SF ratio of 3:20; (B) MTX-Fe3O4-SF nanoparticles (drug load =20%).

Abbreviations: MTX, methotrexate; SEM, scanning electron microscope; SF, silk fibroin.

Figure 3 SEM photographs of nanoparticles.Notes: (A) Fe3O4-SF nanoparticles with an Fe3O4/SF ratio of 3:20; (B) MTX-Fe3O4-SF nanoparticles (drug load =20%).Abbreviations: MTX, methotrexate; SEM, scanning electron microscope; SF, silk fibroin.

Figure 4 Drug load and encapsulation efficiency of MTX-Fe3O4-SF nanoparticles.

Abbreviations: MTX, methotrexate; SF, silk fibroin.

Figure 4 Drug load and encapsulation efficiency of MTX-Fe3O4-SF nanoparticles.Abbreviations: MTX, methotrexate; SF, silk fibroin.

Figure 5 The cumulative permeation of MTX across the skin.

Notes: @, #, and & indicate the statistical significant difference when compared with the stationary magnetic field, the alternating magnetic field, and the stationary/alternating magnetic field, respectively. P<0.05.

Abbreviations: MTX, methotrexate; NPs, nanoparticles.

Figure 5 The cumulative permeation of MTX across the skin.Notes: @, #, and & indicate the statistical significant difference when compared with the stationary magnetic field, the alternating magnetic field, and the stationary/alternating magnetic field, respectively. P<0.05.Abbreviations: MTX, methotrexate; NPs, nanoparticles.

Figure 6 Laser scanning microscope images of the penetration of FITC-Fe3O4-SF nanoparticles.

Notes: (A) Control; (B) stationary magnetic field; (C) alternating magnetic field; and (D) stationary/alternating magnetic fields.

Abbreviations: FITC, fluorescein isothiocyanate; SF, silk fibroin.

Figure 6 Laser scanning microscope images of the penetration of FITC-Fe3O4-SF nanoparticles.Notes: (A) Control; (B) stationary magnetic field; (C) alternating magnetic field; and (D) stationary/alternating magnetic fields.Abbreviations: FITC, fluorescein isothiocyanate; SF, silk fibroin.

Figure 7 ATR-FTIR spectra of skin.

Notes: 1: Control. 2: Stationary magnetic field. 3: Alternating magnetic field. 4: Stationary/alternating magnetic fields. (A) ATR-FTIR spectra of skin and (B) ATR-FTIR spectra of stratum corneum in the C-H stretching region between 2,800 and 2,950 cm−1.

Abbreviation: ATR-FTIR, attenuated total reflection Fourier-transform infrared spectroscopy.

Figure 7 ATR-FTIR spectra of skin.Notes: 1: Control. 2: Stationary magnetic field. 3: Alternating magnetic field. 4: Stationary/alternating magnetic fields. (A) ATR-FTIR spectra of skin and (B) ATR-FTIR spectra of stratum corneum in the C-H stretching region between 2,800 and 2,950 cm−1.Abbreviation: ATR-FTIR, attenuated total reflection Fourier-transform infrared spectroscopy.

Figure S1 SEM photographs of Fe3O4-SF nanoparticles in different ratios of SF/Fe3O4.

Notes: SF/Fe3O4= (A) 40:3; (B) 20:3; (C) 10:3; (D) 5:3.

Abbreviations: SEM, scanning electron microscope; SF, silk fibroin.

Figure S1 SEM photographs of Fe3O4-SF nanoparticles in different ratios of SF/Fe3O4.Notes: SF/Fe3O4= (A) 40:3; (B) 20:3; (C) 10:3; (D) 5:3.Abbreviations: SEM, scanning electron microscope; SF, silk fibroin.

Figure S2 Particle size distribution.

Notes: (A) Fe3O4-SF nanoparticles (SF/Fe3O4=20:3) and (B) MTX-Fe3O4-SF nanoparticles.

Abbreviations: MTX, methotrexate; SF, silk fibroin.

Figure S2 Particle size distribution.Notes: (A) Fe3O4-SF nanoparticles (SF/Fe3O4=20:3) and (B) MTX-Fe3O4-SF nanoparticles.Abbreviations: MTX, methotrexate; SF, silk fibroin.

Figure S3 Histopathological analyses of skin.

Notes: (A) Control; (B) stationary magnetic field; (C) alternating magnetic field; and (D) stationary/alternating magnetic field.

Figure S3 Histopathological analyses of skin.Notes: (A) Control; (B) stationary magnetic field; (C) alternating magnetic field; and (D) stationary/alternating magnetic field.

Table S1 Permeation coefficient of MTX solution and MTX-Fe3O4-SF NPs

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