Figures & data
Figure 1 A simplified design for a magnetic drug delivery system in which magnetic nanoparticles coated with drugs are directed to infection sites by an external magnetic field.
Figure 2 Transmission electron microscope images of the synthesized IO/PVA nanoparticles. Scale bar = 20 nm.
Abbreviations: IO, iron oxide; PVA, polyvinyl alcohol.
Figure 3 IO nanoparticle size distribution as measured by dynamic light scattering.
Abbrevation: IO, iron oxide.
Figure 4 Zeta potential of IO nanoparticles in an aqueous solution was measured by a Malvern Zetasizer-nano instrument. Average zeta potential was −19.09 mV.
Abbreviation: IO, iron oxide.
Figure 5 X-ray diffraction results of synthesized nanoparticles confirmed the existence of magnetite (Fe3O4) and maghemite γ-Fe2O3.
Figure 6 Magnetization curves of IO/PVA nanoparticles as measured by VSM at room temperature. The results clearly showed superparamagnetic behavior of the nanoparticles.
Abbreviations: IO, iron oxide; PVA, polyvinyl alcohol; VSM, vibrating sample magnometry.
Figure 7 Optical density reading of bacteria in IO/PVA solution after four hours, 12 hours, and 24 hours. The results are mean ± SEM. (n = 3). All densities are significantly (*P < 0.01) greater at 12 and 24 hours compared with the four-hour time point.
Abbreviations: IO, iron oxide; PVA, polyvinyl alcohol.
Figure 8 Live/dead assay results showed lower live/dead ratios in the presence of the high dose (3 mg/mL) IO/PVA nanoparticle solution after incubation for A) four hours, B) 12 hours, and C) 24 hours. Data = mean ± SEM; n = 3. *P < 0.05 compared with control sample and samples with low (30 mg/mL) and medium doses (300 mg/mL) of IO nanoparticles.
Abbreviations: IO, iron oxide; PVA, polyvinyl alcohol.
