Impact of single-walled carbon nanotubes on the embryo: a brief review

Figures & data

Figure 1 Different types of CNTs: (A) SWCNT and (B) MWCNT.

Abbreviations: CNTs, carbon nanotubes; MWCNT, multiwalled carbon nanotube; SWCNT, single-walled carbon nanotube.

Table 1 Summarize the outcome of SWCNTs on the embryo

Embryo	Outcome	References
Drosophila	No toxicity	^Citation62, ^Citation63
Zebrafish	Hatching delay	^Citation26, ^Citation30
Avian	Cytotoxic effect on glial and neurons cells	^Citation64
	Inhibition of angiogenesis, gene deregulation, and abnormal development	^Citation28
Mouse	Increase of reactive oxygen species, malformation, and skeletal abnormalities	^Citation63, ^Citation65
	Cytotoxic effects and DNA damages on embryonic cells	^Citation66
	Low cell proliferation and viability of glioblastoma cells	^Citation67
	Apoptotic effect and DNA damage on mouse embryonic cells	^Citation29
Hamster	Cytotoxic and genotoxic effects on embryonic cells	^Citation52

Abbreviation: SWCNT, single-walled carbon nanotube.

Figure 2 Outcome of SWCNTs on the chicken embryo at 12 days of incubation.

Notes: The SWCNTs-exposed embryo (A) is smaller in comparison with its matched control (B). Additionally, we note that SWCNTs inhibit blood vessels development in SWCNTs-treated embryo in comparison with the control (arrows). The embryos were treated by 25 μg of SWCNTs at 3 days of incubation, reprinted from Nanomedicine, 2013;9(7), Roman D, Yasmeen A, Mireuta M, Stiharu I, Al Moustafa AE, Significant toxic role for single-walled carbon nanotubes during normal embryogenesis, Pages 945–950,²⁸ Copyright ©2013, with permission from Elsevier.

Abbreviation: SWCNTs, single-walled carbon nanotubes.

Figure 3 Schematic showing the relationship between SWCNTs and embryotoxicity.

Notes: Water and/or food could be contaminated by SWCNTs; therefore, these particles can penetrate organism and embryonic cells and thereby induce apoptosis and/or cell death via the alteration of their key regulators genes.

Abbreviation: SWCNTs, single-walled carbon nanotubes.

LeeuwTKReithRMSimonetteRASingle-walled carbon nanotubes in the intact organism: near-IR imaging and biocompatibility studies in DrosophilaNano Lett2007792650265417696559

 PubMed Web of Science ®Google Scholar

PhilbrookNAWalkerVKAfroozARSalehNBWinnLMInvestigating the effects of functionalized carbon nanotubes on reproduction and development in Drosophila melanogaster and CD-1 miceReprod Toxicol201132444244821963887

 PubMed Web of Science ®Google Scholar

ChengJChanCMVecaLMAcute and long-term effects after single loading of functionalized multi-walled carbon nanotubes into zebrafish (Danio rerio)Toxicol Appl Pharmacol2009235221622519133284

 PubMed Web of Science ®Google Scholar

OngKJZhaoXThistleMEMechanistic insights into the effect of nanoparticles on zebrafish hatchNanotoxicology20148329530423421642

 PubMed Web of Science ®Google Scholar

BelyanskayaLWeigelSHirschCToblerUKrugHFWickPEffects of carbon nanotubes on primary neurons and glial cellsNeurotoxicology200930470271119465056

 PubMed Web of Science ®Google Scholar

RomanDYasmeenAMireutaMStiharuIAl MoustafaAESignificant toxic role for single-walled carbon nanotubes during normal embryogenesisNanomedicine20139794595023563045

 PubMed Web of Science ®Google Scholar

PietroiustiAMassimianiMFenoglioILow doses of pristine and oxidized single-wall carbon nanotubes affect mammalian embryonic developmentACS Nano2011564624463321615177

 PubMed Web of Science ®Google Scholar

YangHLiuCYangDZhangHXiZComparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and compositionJ Appl Toxicol2009291697818756589

 PubMed Web of Science ®Google Scholar

BobrinetskiiIIMorozovRASeleznevASPodchernyaevaRYLopatinaOAProliferative activity and viability of fibroblast and glioblastoma cell on various types of carbon nanotubesBull Exp Biol Med2012153225926222816097

 PubMedGoogle Scholar

TongLZhangWHangHYuZChuPKXuAToxicity of carbon nanotubes to p21 and hus1 gene deficient mammalian cellsJ Nanosci Nanotechnol20111112110011100522409043

 PubMed Web of Science ®Google Scholar

DarneCTerzettiFCoulaisCCytotoxicity and genotoxicity of panel of single- and multiwalled carbon nanotubes: in vitro effects on normal Syrian hamster embryo and immortalized v79 hamster lung cellsJ Toxicol2014201487219525548561

 PubMedGoogle Scholar