Population-based estimation of renal function in healthy young Indian adults based on body mass index and sex correlating renal volume, serum creatinine, and cystatin C

Figures & data

Table 1 Baseline demographics of our patient population

Demographic	Mean ± SD
Age	25±6
Random blood sugar	91±40
BMI	22.3±2.5
Systolic blood pressure	114±9
Diastolic blood pressure	72±6
Birth weight	2.6±0.4

Abbreviations: SD, standard deviation; BMI, body mass index.

Table 2 Serum creatinine, cystatin C, and estimated creatinine clearance according to BMI

BMI (kg/m^2)	n (%)	Creatinine (mg/dL)	Cystatin C (mg/dL)	eGFR CG CrCL (mL/min)	eGFR MDRD (mL/min)	eGFR (cystatin C based; mL/min)
<18.5	168 (17)	1.03±0.12	0.94±0.17*	71.29±10.45*	76.70±19.74	84.53±18.14
18.5–24.99	557 (57)	1.04±0.13	0.95±0.16	86.38±13.46*	76.44±11.54	84.01±40.11
25–29.99	202 (21)	1.06±0.12	0.99±0.16*	98.88±15.29*	76.87±12.57	79.18±13.46
≥30	51 (5)	1.05±0.13	1±0.13	109.13±21.57*	75.55±11.88	77.30±10.90
Total	978 (100)	1.05±0.13	0.96±0.16	87.56±17.05	76.53±11.63	82.75±31.95

Note:

* P-value <0.05 via post hoc Tukey’s test between the subgroups in a column.

Abbreviations: BMI, body mass index; n, number of patients; eGFR, estimated glomerular filtration rate; CG CrCL, Cockcroft and Gault-based creatinine clearance; min, minute; MDRD, Modification of Diet in Renal Disease.

Table 4 Serum creatinine, cystatin C, and estimated creatinine clearance according to BMI and sex

Sex	BMI (kg/m^2)	n	Creatinine (mg/dL)	Cystatin C (mg/dL)	eGFR	eGFR MDRD (mL/min)	eGFR (cystatin C based; mL/min)
Female	<18.5	136	1.01±0.10	0.92±0.17	72.02±10.56	70.13±9.24	113.03±23.20
	18.5–24.99	388	1.01±0.12	0.93±0.16	87.11±13.74	69.06±10.27	112.54±49.15
	25–29.99	112	1.02±0.11	0.98±0.14	100.13±15.63	89.38±12.01	104.03±16.18
	≥30	36	1.01±0.10	0.98±0.12	108.56±21.27	91.63±10.00	104.14±12.98
Male	<18.5	32	1.13±0.11	1.02±0.15	68.52±9.53	59.79±6.92	100.15±15.95
	18.5–24.99	169	1.13±0.10	1.00±0.15	84.79±12.89	78.49±9.29	104.60±48.64
	25–29.99	90	1.11±0.12	0.99±0.17	97.49±14.80	79.55±10.85	103.42±17.52
	≥30	15	1.14±0.15	1.07±0.14	110.50±22.96	78.49±15.02	95.42±13.39

Abbreviations: BMI, body mass index; n, number of patients; eGFR, estimated glomerular filtration rate; MDRD, Modification of Diet in Renal Disease; min, minute.

Table 5 Ultrasound-based renal volume according to sex and BMI

Group	BMI classification criteria (kg/m^2)	Kidney volume (R +L; cc)
		Male	Female
1	<18.5	177.20+35.23	149.28+30.17
2	18.5–24.99	198.70+46.41	164.72+33.04
3	25–29.99	205.33+49.46	175.74+32.05
4	≥30	228.23+62.04	201.85+49.68

Abbreviations: BMI, body mass index; R, right; L, left.

Table 3 Serum creatinine, cystatin C, and estimated creatinine clearance according to sex

Sex	n (%)	Creatinine (mg/dL)	Cystatin C (mg/dL)	eGFR CG CrCL (mL/min)	eGFR MDRD (mL/min)	eGFR (cystatin C based; mL/min)
Female	672 (68.7)	1.01±0.11*	0.94±.016*	87.38±17.09	73.81±13.40*	84.75±31.81*
Male	306 (31.2)	1.12±0.10*	1.01±0.15*	88.14±16.88	76.8±11.46*	78.7±30.21*
Total	978 (100)	1.05±0.13	0.96±0.16	87.62±17.02	74.77±12.8	82.8±31.4

Note:

* P-value <0.05 via post hoc Tukey’s test between the subgroups in a column.

Abbreviations: n, number of patients; eGFR, estimated glomerular filtration rate; CG CrCL, Cockcroft and Gault-based creatinine clearance; min, minute; MDRD, Modification of Diet in Renal Disease.