Review of eprodisate for the treatment of renal disease in AA amyloidosis

Figures & data

Table 1 List of causes of AA amyloid in order of incidence

Rheumatoid arthritis

Juvenile idiopathic arthritis

Other chronic inflammatory arthritides

Bronchiectasis

Familial Mediterranean fever

Unknown cause

Crohn’s disease

Other source of chronic sepsis (osteomyelitis, tuberculosis, etc)

Injection-drug abuse

Complications of paraplegia

Castleman’s disease

TNF-receptor associated periodic fever syndrome

Neoplasia

Vasculitis

Muckle–Wells syndrome

Abbreviation: TNF, tumor necrosis factor.

Figure 1 The pathogenesis of amyloid fibrils.

Abbreviations: SAA, serum amyloid A; IL-1, interleukin-1; IL-6, interleukin 6; TNF-α, tumour necrosis factor alpha; GAG, glycosaminoglycan; SAP, serum amyloid P.

Figure 2 The chemical structure of 1,3 propanedisulfonic acid disodium salt.