Figures & data
Figure 1 Manifestations of thrombotic microangiopathy and the clinical presentations of end-organ damage. Data from references.Citation3–Citation16
![Figure 1 Manifestations of thrombotic microangiopathy and the clinical presentations of end-organ damage. Data from references.Citation3–Citation16](/cms/asset/74516a81-3df5-4126-ab2a-8e0314720cbe/dnrd_a_12173824_f0001_c.jpg)
Figure 2 The alternative complement pathway in atypical hemolytic uremic syndrome and the associated genetic mutations.
Abbreviations: CFB, complement factor B; CFD, complement factor D; CFI, complement factor I; CFH, complement factor H; MCP, membrane cofactor protein; THBD, thrombomodulin; MAC, membrane attack complex; CFHR, complement factor receptor; PLG, plasminogen; INF2, Inverted Formin 2; aHUS, atypical hemolytic uremic syndrome.
![Figure 2 The alternative complement pathway in atypical hemolytic uremic syndrome and the associated genetic mutations.](/cms/asset/f46a7610-c8ed-4f42-956f-02532aaf445c/dnrd_a_12173824_f0002_c.jpg)
Table 1 Dosing regimen for eculizumab in patients with atypical hemolytic uremic syndrome
Figure 3 Sustained increase in platelet count during ongoing eculizumab treatment in trial 1 data (from Soliris (Eculizumab) highlights of prescribing information. US Food and Drug Administration. 2007. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/125166s172lbl.pdfCitation36) (bars represent SD); normalization of platelet count was defined as count >150±109/L).
![Figure 3 Sustained increase in platelet count during ongoing eculizumab treatment in trial 1 data (from Soliris (Eculizumab) highlights of prescribing information. US Food and Drug Administration. 2007. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/125166s172lbl.pdfCitation36) (bars represent SD); normalization of platelet count was defined as count >150±109/L).](/cms/asset/e03279e6-f586-4a55-b792-2323ba82f8aa/dnrd_a_12173824_f0003_c.jpg)
Figure 4 Improved renal function through 2 years with ongoing eculizumab treatment in trial 2 data (from Soliris (Eculizumab) highlights of prescribing information. US Food and Drug Administration. 2007. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/125166s172lbl.pdfCitation36) (bars represent SD); normalization of platelet count was defined as count >150±109/L).
![Figure 4 Improved renal function through 2 years with ongoing eculizumab treatment in trial 2 data (from Soliris (Eculizumab) highlights of prescribing information. US Food and Drug Administration. 2007. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/125166s172lbl.pdfCitation36) (bars represent SD); normalization of platelet count was defined as count >150±109/L).](/cms/asset/2c4cb5e3-cb8c-4f88-b368-a10c50a97412/dnrd_a_12173824_f0004_c.jpg)
Figure 5 Markers evaluated at baseline in patients with aHUSCitation41
![Figure 5 Markers evaluated at baseline in patients with aHUSCitation41](/cms/asset/11b6b809-a1af-44a4-b724-69bd049ea2ec/dnrd_a_12173824_f0005_c.jpg)
Table 2 Clinical trials and studies on eculizumab
Table 3 Monitoring of eculizumab therapy and complement activity in atypical hemolytic uremic syndrome (aHUS)
Table 4 Studies describing the outcome of eculizumab regimen discontinuation in aHUS patients
Table 5 Frequency of patients with mutations and ESRD in aHUS