Level of 8-OHdG in drained dialysate appears to be a marker of peritoneal damage in peritoneal dialysis

Figures & data

Figure 1 The level of 8-hydroxydeoxyguanosine (8-OHdG) in drained dialysate in peritoneal dialysis (PD) patients. Comparison of 8-OHdG levels in drained dialysate between (A) males and females, (B) those who had diabetic nephropathy (DMN) and those who did not (non-DMN), and (C) those who had a past history of peritonitis and those who did not.

Note: Columns represent the mean plus or minus standard error.
Abbreviation: NS, no statistical significance.

Table 1 Patients’ baseline characteristics (N = 28)

Parameter	Statistics
Age (years)	56.3 ± 13.1
Gender
Male	18
Female	10
BMI (kg/m^2)	23.4 ± 4.3
Duration of PD (years)	1.9 ± 2.1
Peritonitis history (number of times)
0	19
1	5
2	2
3	1
4	1
Initial nephropathy
Chronic glomerulonephritis	11
Diabetic nephropathy	8
Lupus nephritis	1
Drug nephropathy	1
Renal sclerosis	2
Gout kidney	1
Unknown	4
SBP (mmHg)	146.5 ± 27.6
DBP (mmHg)	83.3 ± 12.8
Hemoglobin (g/dL)	9.8 ± 1.3
Albumin (g/dL)	3.2 ± 0.3

Note: Age, BMI, duration of PD, SBP, DBP, hemoglobin, and albumin data are expressed as the mean plus or minus the standard deviation.

Abbreviations: BMI, body mass index; DBP, diastolic blood pressure; PD, peritoneal dialysis; SBP, systolic blood pressure.

Figure 2 Correlation between the 8-hydroxydeoxyguanosine (8-OHdG) level in drained dialysate and the peritoneal solute transport rate, determined by peritoneal equilibration test and matrix metalloproteinase-2 (MMP-2) level in drained dialysate: 8-OHdG level and (A) dialysate:plasma creatine ratio (D/P Cr), D/D0 glucose (where D is the glucose level of peritoneal effluents obtained 4 hours after the injection and D0 is the glucose level obtained immediately after the injection), and MMP-2 level in peritoneal dialysis (PD) patients and (B) D/P Cr, D/D0 glucose, and MMP-2 level in those PD patients who had a past history of peritonitis and in those PD patients who did not.

Figure 3 Correlation between the 8-hydroxydeoxyguanosine (8-OHdG) level in drained dialysate and the peritoneal dialysis (PD) duration and age of subject: 8-OHdG level and (A) PD duration and age of subject and (B) systolic blood pressure (SBP) and diastolic blood pressure (DBP).