https://orcid.org/0000-0002-2979-7450
Figures & data
Figure 1 Probable mechanisms for the development of CKDu. Those includes (A) the uptake of toxins in the tubules, resulting in direct toxicity. (B) Heat exposure resulting in dehydration and rise in core temperature, which might cause kidney injury directly through tissue dysfunction or indirectly through rhabdomyolysis or hyperosmolarity. Furthermore, heat-associated dehydration may also cause kidney injury by strengthening the renal effects of toxins. (C) It has also been suggested that infectious agents may be involved in the pathogenesis of CKDu. For all mechanisms, genetic factors could be essential.
