Nephrolithiasis in patients with inflammatory bowel disease in the community

Figures & data

Table 1 Baseline characteristics of patients

Variable	CD (n = 93)	UC (n = 75)
Mean age (years)	41	43
Female (%)	52	75
Prior surgery (%)	2	0
Disease geography (%)
Ileal disease	69	0
Pancolitis	0	21
Active at enrollment (%)	24	16
Current medications (%)
Mesalazine	98	100
Prednisone	50	47
Thiopurine	42	37
Anti-TNF	36	4
Methotrexate	18	2
Antibiotics	24	8

Abbreviations: CD, Crohn’s disease; UC, ulcerative colitis; TNF, tumor necrosis factor.

Table 2 Univariate factors associated with renal calculi

Variable	CD (n = 93)	UC (n = 75)
Disease activity (UC)	–	OR 4.2 (95% CI 1.1–15, P = 0.02)
Disease location (L3)	OR 2.3 (95% CI 1.8–7, P = 0.007)	–
Steroids	–	OR 2.9 (95% CI 1.1–7, P = 0.03)
Ciprofloxacin	OR 5.2 (95% CI 1.9–14, P = 0.002)	OR 10 (95% CI 1.1–90, P = 0.03)
Immunomodulator	OR 4.2 (1.7–10, P = 0.001)	OR 3.9 (95% CI 1.4–10, P = 0.006)
Metronidazole	OR 3.5 (95% CI 1.3–9.8, P = 0.002)	OR 12 (95% CI 1.5–110, P = 0.01)
Methotrexate	OR 3.8 (95% CI 1.3–11, P = 0.01)	–

Abbreviations: CD, Crohn’s disease; UC, ulcerative colitis; OR, odds ratio; CI, confidence interval.